The chronic myeloid leukaemias: Guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia. Proposals by the French-American-British cooperative leukaemia group

J. M. Bennett, D. Catovsky, M. T. Daniel, G. Flandrin, D. A.G. Galton, H. Gralnick, C. Sultan, C. Cox

Research output: Contribution to journalArticlepeer-review

Abstract

We have reviewed our experience with four of the entities that are included under the generic term chronic myeloid leukaemia (CML), namely the classic Ph+ CGL, both BCR+ and BCR-, aCML and CMML. We have developed a statistical model that confirms that CGL, aCML and CMML can be distinguished from each other with reasonable success employing five quantitative parameters (WBC, percentage immature granulocytes, percentage monocytes, percentage basophils, percentage erythroid precursors in bone marrow) and one qualitative parameter (granulocytic dysplasia). It is hoped that these detailed recommendations will enable investigators to improve their diagnostic accuracy. This should permit more uniform comparisons of molecular biologic and clinical studies.

Original languageEnglish (US)
Pages (from-to)746-754
Number of pages9
JournalBritish journal of haematology
Volume87
Issue number4
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Keywords

  • Atypical CML
  • CMML
  • Chronic myeloid leukaemias
  • Philadelphia-negative CML

ASJC Scopus subject areas

  • Hematology

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