TY - JOUR
T1 - The chronic myeloid leukaemias
T2 - Guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia. Proposals by the French-American-British cooperative leukaemia group
AU - Bennett, J. M.
AU - Catovsky, D.
AU - Daniel, M. T.
AU - Flandrin, G.
AU - Galton, D. A.G.
AU - Gralnick, H.
AU - Sultan, C.
AU - Cox, C.
PY - 1994
Y1 - 1994
N2 - We have reviewed our experience with four of the entities that are included under the generic term chronic myeloid leukaemia (CML), namely the classic Ph+ CGL, both BCR+ and BCR-, aCML and CMML. We have developed a statistical model that confirms that CGL, aCML and CMML can be distinguished from each other with reasonable success employing five quantitative parameters (WBC, percentage immature granulocytes, percentage monocytes, percentage basophils, percentage erythroid precursors in bone marrow) and one qualitative parameter (granulocytic dysplasia). It is hoped that these detailed recommendations will enable investigators to improve their diagnostic accuracy. This should permit more uniform comparisons of molecular biologic and clinical studies.
AB - We have reviewed our experience with four of the entities that are included under the generic term chronic myeloid leukaemia (CML), namely the classic Ph+ CGL, both BCR+ and BCR-, aCML and CMML. We have developed a statistical model that confirms that CGL, aCML and CMML can be distinguished from each other with reasonable success employing five quantitative parameters (WBC, percentage immature granulocytes, percentage monocytes, percentage basophils, percentage erythroid precursors in bone marrow) and one qualitative parameter (granulocytic dysplasia). It is hoped that these detailed recommendations will enable investigators to improve their diagnostic accuracy. This should permit more uniform comparisons of molecular biologic and clinical studies.
KW - Atypical CML
KW - CMML
KW - Chronic myeloid leukaemias
KW - Philadelphia-negative CML
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U2 - 10.1111/j.1365-2141.1994.tb06734.x
DO - 10.1111/j.1365-2141.1994.tb06734.x
M3 - Article
C2 - 7986717
AN - SCOPUS:0028069002
SN - 0007-1048
VL - 87
SP - 746
EP - 754
JO - British journal of haematology
JF - British journal of haematology
IS - 4
ER -