The cholinergic hypothesis revisited – an unfinished story

Robert S. Fitzgerald; Machiko Shirahata; Tohru Ide; Ralph Lydic

doi:10.1159/000109456

The cholinergic hypothesis revisited – an unfinished story

Robert S. Fitzgerald, Machiko Shirahata, Tohru Ide, Ralph Lydic

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Though exogenously delivered acetylcholine excites the carotid body, past evidence has been considered as unsupportive in assigning acetylcholine an excitatory role during hypoxia or hypercapnia. With ganglionic transmission used as the model, data is presented which aims at blocking the postsynaptic cholinergic receptors, at preventing the presynaptic release of acetylcholine, and at quantitating its release under stimulating conditions. The data support an excitatory role for acetylcholine during hypoxia.

Original language	English (US)
Pages (from-to)	298-303
Number of pages	6
Journal	NeuroSignals
Volume	4
Issue number	5
DOIs	https://doi.org/10.1159/000109456
State	Published - Jan 1 1995

Keywords

Acetylcholine
Atropine
Cholinergic hypothesis
Cholinergic receptors
Gallamine
Mecamylamine
Pirenzepine
Vesamicol

ASJC Scopus subject areas

Neurology
Developmental Neuroscience
Cellular and Molecular Neuroscience

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N2 - Though exogenously delivered acetylcholine excites the carotid body, past evidence has been considered as unsupportive in assigning acetylcholine an excitatory role during hypoxia or hypercapnia. With ganglionic transmission used as the model, data is presented which aims at blocking the postsynaptic cholinergic receptors, at preventing the presynaptic release of acetylcholine, and at quantitating its release under stimulating conditions. The data support an excitatory role for acetylcholine during hypoxia.

AB - Though exogenously delivered acetylcholine excites the carotid body, past evidence has been considered as unsupportive in assigning acetylcholine an excitatory role during hypoxia or hypercapnia. With ganglionic transmission used as the model, data is presented which aims at blocking the postsynaptic cholinergic receptors, at preventing the presynaptic release of acetylcholine, and at quantitating its release under stimulating conditions. The data support an excitatory role for acetylcholine during hypoxia.

KW - Acetylcholine

KW - Atropine

KW - Cholinergic hypothesis

KW - Cholinergic receptors

KW - Gallamine

KW - Mecamylamine

KW - Pirenzepine

KW - Vesamicol

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The cholinergic hypothesis revisited – an unfinished story

Abstract

Keywords

ASJC Scopus subject areas

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