The cholinergic hypothesis revisited – an unfinished story

Robert S. Fitzgerald, Machiko Shirahata, Tohru Ide, Ralph Lydic

Research output: Contribution to journalArticle

Abstract

Though exogenously delivered acetylcholine excites the carotid body, past evidence has been considered as unsupportive in assigning acetylcholine an excitatory role during hypoxia or hypercapnia. With ganglionic transmission used as the model, data is presented which aims at blocking the postsynaptic cholinergic receptors, at preventing the presynaptic release of acetylcholine, and at quantitating its release under stimulating conditions. The data support an excitatory role for acetylcholine during hypoxia.

Original languageEnglish (US)
Pages (from-to)298-303
Number of pages6
JournalNeuroSignals
Volume4
Issue number5
DOIs
StatePublished - Jan 1 1995

Keywords

  • Acetylcholine
  • Atropine
  • Cholinergic hypothesis
  • Cholinergic receptors
  • Gallamine
  • Mecamylamine
  • Pirenzepine
  • Vesamicol

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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