The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium

Design, methods, and study population

James E. Gern, Daniel J. Jackson, Robert F. Lemanske, Christine M. Seroogy, Umberto Tachinardi, Mark Craven, Stephen Y. Hwang, Carol M. Hamilton, Wayne Huggins, George T. O'Connor, Diane R. Gold, Rachel Miller, Meyer Kattan, Christine C. Johnson, Dennis Ownby, Edward M. Zoratti, Robert A Wood, Cynthia M. Visness, Fernando Martinez, Anne Wright & 6 others Susan Lynch, Carole Ober, Gurjit K. Khurana Hershey, Patrick Ryan, Tina Hartert, Leonard B. Bacharier

Research output: Contribution to journalArticle

Abstract

Background: Single birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and population. The Children's Respiratory and Environmental Workgroup (CREW) was established to integrate multiple established asthma birth cohorts and to investigate asthma phenotypes and associated causal pathways (endotypes), focusing on how they are influenced by interactions between genetics, lifestyle, and environmental exposures during the prenatal period and early childhood. Methods and results: CREW is funded by the NIH Environmental influences on Child Health Outcomes (ECHO) program, and consists of 12 individual cohorts and three additional scientific centers. The CREW study population is diverse in terms of race, ethnicity, geographical distribution, and year of recruitment. We hypothesize that there are phenotypes in childhood asthma that differ based on clinical characteristics and underlying molecular mechanisms. Furthermore, we propose that asthma endotypes and their defining biomarkers can be identified based on personal and early life environmental risk factors. CREW has three phases: 1) to pool and harmonize existing data from each cohort, 2) to collect new data using standardized procedures, and 3) to enroll new families during the prenatal period to supplement and enrich extant data and enable unified systems approaches for identifying asthma phenotypes and endotypes. Conclusions: The overall goal of CREW program is to develop a better understanding of how early life environmental exposures and host factors interact to promote the development of specific asthma endotypes.

Original languageEnglish (US)
Article number115
JournalRespiratory research
Volume20
Issue number1
DOIs
StatePublished - Jun 10 2019

Fingerprint

Asthma
Parturition
Population
Environmental Exposure
Phenotype
Sample Size
Life Style
Cohort Studies
Biomarkers

Keywords

  • Allergy
  • Asthma
  • Birth cohort
  • Children
  • Development
  • Environment
  • Longitudinal study

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Gern, J. E., Jackson, D. J., Lemanske, R. F., Seroogy, C. M., Tachinardi, U., Craven, M., ... Bacharier, L. B. (2019). The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: Design, methods, and study population. Respiratory research, 20(1), [115]. https://doi.org/10.1186/s12931-019-1088-9

The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium : Design, methods, and study population. / Gern, James E.; Jackson, Daniel J.; Lemanske, Robert F.; Seroogy, Christine M.; Tachinardi, Umberto; Craven, Mark; Hwang, Stephen Y.; Hamilton, Carol M.; Huggins, Wayne; O'Connor, George T.; Gold, Diane R.; Miller, Rachel; Kattan, Meyer; Johnson, Christine C.; Ownby, Dennis; Zoratti, Edward M.; Wood, Robert A; Visness, Cynthia M.; Martinez, Fernando; Wright, Anne; Lynch, Susan; Ober, Carole; Khurana Hershey, Gurjit K.; Ryan, Patrick; Hartert, Tina; Bacharier, Leonard B.

In: Respiratory research, Vol. 20, No. 1, 115, 10.06.2019.

Research output: Contribution to journalArticle

Gern, JE, Jackson, DJ, Lemanske, RF, Seroogy, CM, Tachinardi, U, Craven, M, Hwang, SY, Hamilton, CM, Huggins, W, O'Connor, GT, Gold, DR, Miller, R, Kattan, M, Johnson, CC, Ownby, D, Zoratti, EM, Wood, RA, Visness, CM, Martinez, F, Wright, A, Lynch, S, Ober, C, Khurana Hershey, GK, Ryan, P, Hartert, T & Bacharier, LB 2019, 'The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: Design, methods, and study population', Respiratory research, vol. 20, no. 1, 115. https://doi.org/10.1186/s12931-019-1088-9
Gern, James E. ; Jackson, Daniel J. ; Lemanske, Robert F. ; Seroogy, Christine M. ; Tachinardi, Umberto ; Craven, Mark ; Hwang, Stephen Y. ; Hamilton, Carol M. ; Huggins, Wayne ; O'Connor, George T. ; Gold, Diane R. ; Miller, Rachel ; Kattan, Meyer ; Johnson, Christine C. ; Ownby, Dennis ; Zoratti, Edward M. ; Wood, Robert A ; Visness, Cynthia M. ; Martinez, Fernando ; Wright, Anne ; Lynch, Susan ; Ober, Carole ; Khurana Hershey, Gurjit K. ; Ryan, Patrick ; Hartert, Tina ; Bacharier, Leonard B. / The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium : Design, methods, and study population. In: Respiratory research. 2019 ; Vol. 20, No. 1.
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T2 - Design, methods, and study population

AU - Gern, James E.

AU - Jackson, Daniel J.

AU - Lemanske, Robert F.

AU - Seroogy, Christine M.

AU - Tachinardi, Umberto

AU - Craven, Mark

AU - Hwang, Stephen Y.

AU - Hamilton, Carol M.

AU - Huggins, Wayne

AU - O'Connor, George T.

AU - Gold, Diane R.

AU - Miller, Rachel

AU - Kattan, Meyer

AU - Johnson, Christine C.

AU - Ownby, Dennis

AU - Zoratti, Edward M.

AU - Wood, Robert A

AU - Visness, Cynthia M.

AU - Martinez, Fernando

AU - Wright, Anne

AU - Lynch, Susan

AU - Ober, Carole

AU - Khurana Hershey, Gurjit K.

AU - Ryan, Patrick

AU - Hartert, Tina

AU - Bacharier, Leonard B.

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N2 - Background: Single birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and population. The Children's Respiratory and Environmental Workgroup (CREW) was established to integrate multiple established asthma birth cohorts and to investigate asthma phenotypes and associated causal pathways (endotypes), focusing on how they are influenced by interactions between genetics, lifestyle, and environmental exposures during the prenatal period and early childhood. Methods and results: CREW is funded by the NIH Environmental influences on Child Health Outcomes (ECHO) program, and consists of 12 individual cohorts and three additional scientific centers. The CREW study population is diverse in terms of race, ethnicity, geographical distribution, and year of recruitment. We hypothesize that there are phenotypes in childhood asthma that differ based on clinical characteristics and underlying molecular mechanisms. Furthermore, we propose that asthma endotypes and their defining biomarkers can be identified based on personal and early life environmental risk factors. CREW has three phases: 1) to pool and harmonize existing data from each cohort, 2) to collect new data using standardized procedures, and 3) to enroll new families during the prenatal period to supplement and enrich extant data and enable unified systems approaches for identifying asthma phenotypes and endotypes. Conclusions: The overall goal of CREW program is to develop a better understanding of how early life environmental exposures and host factors interact to promote the development of specific asthma endotypes.

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KW - Birth cohort

KW - Children

KW - Development

KW - Environment

KW - Longitudinal study

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