The chemokine growth-regulated oncogene-α promotes spinal cord oligodendrocyte precursor proliferation

Shenandoah Robinson, Marie Tani, Robert M. Stricter, Richard M. Ransohoff, Robert H. Miller

Research output: Contribution to journalArticlepeer-review

Abstract

Chemokines, (chemotactic cytokines) are a family of regulatory molecules involved in modulating inflammatory responses. Here we demonstrate that the chemokine growth-regulated oncogene-α (GRO-α) is a potent promoter of oligodendrocyte precursor proliferation. The proliferative response of immature spinal cord oligodendrocyte precursors to their major mitogen, platelet derived growth factor (PDGF), is dramatically enhanced by GRO-α present in spinal cord conditioned medium. One source of GRO-α is a subset of spinal cord astrocytes. Cultures of astrocytes contain GRO-α mRNA and protein and secrete biologically active concentrations of GRO-α. In postnatal spinal cord white matter the location of GRO-α-immunoreactive cells is developmentally regulated: GRO-α+ cells first appear in ventral and later in dorsal spinal cord white matter. These results suggest that localized proliferation of oligodendrocytes is mediated by synergy between PDGF and GRO-α.

Original languageEnglish (US)
Pages (from-to)10457-10463
Number of pages7
JournalJournal of Neuroscience
Volume18
Issue number24
DOIs
StatePublished - Dec 15 1998

Keywords

  • Cell proliferation
  • Chemokines
  • Development
  • GRO-α
  • Oligodendrocytes
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)

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