The characterization of the Olf-1/EBF-like HLH transcription factor family: Implications in olfactory gene regulation and neuronal development

Song S. Wang, Robert Y.L. Tsai, Randall R. Reed

Research output: Contribution to journalArticlepeer-review

Abstract

The Olf-1/EBF helix-loop-helix (HLH) transcription factor has been implicated in olfactory gene regulation and in B-cell development. Using homology screening methods, we identified two additional Olf-1/EBF-like cDNAs from a mouse embryonic cDNA library. The Olf-1/EBF-like (O/E) proteins O/E- 1, O/E-2, and O/E-3 define a family of transcription factors that share structural similarities and biochemical activities. Although these O/E genes are expressed within olfactory epithelium in an identical pattern, they exhibit different patterns of expression in the developing nervous system. Although O/E-1 mRNA is present in several tissues in addition to olfactory neurons and developing B-cells, O/E-2 and O/E-3 are expressed at high levels only in olfactory tissue. In O/E-1 knock-out animals, the presence of two additional O/E family members in olfactory neurons may provide redundancy and allow normal olfactory neurodevelopment. Further, the identification of the O/E family of HLH transcription factors and their embryonic expression patterns suggest that the O/E proteins may have a more general function in neuronal development.

Original languageEnglish (US)
Pages (from-to)4149-4158
Number of pages10
JournalJournal of Neuroscience
Volume17
Issue number11
DOIs
StatePublished - 1997

Keywords

  • O/E
  • Olf-1/EBF
  • differentiation and maturation
  • neurodevelopment
  • olfactory gene regulation
  • sensory neurons
  • transcription factors

ASJC Scopus subject areas

  • Neuroscience(all)

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