Abstract
The Olf-1/EBF helix-loop-helix (HLH) transcription factor has been implicated in olfactory gene regulation and in B-cell development. Using homology screening methods, we identified two additional Olf-1/EBF-like cDNAs from a mouse embryonic cDNA library. The Olf-1/EBF-like (O/E) proteins O/E- 1, O/E-2, and O/E-3 define a family of transcription factors that share structural similarities and biochemical activities. Although these O/E genes are expressed within olfactory epithelium in an identical pattern, they exhibit different patterns of expression in the developing nervous system. Although O/E-1 mRNA is present in several tissues in addition to olfactory neurons and developing B-cells, O/E-2 and O/E-3 are expressed at high levels only in olfactory tissue. In O/E-1 knock-out animals, the presence of two additional O/E family members in olfactory neurons may provide redundancy and allow normal olfactory neurodevelopment. Further, the identification of the O/E family of HLH transcription factors and their embryonic expression patterns suggest that the O/E proteins may have a more general function in neuronal development.
Original language | English (US) |
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Pages (from-to) | 4149-4158 |
Number of pages | 10 |
Journal | Journal of Neuroscience |
Volume | 17 |
Issue number | 11 |
DOIs | |
State | Published - 1997 |
Keywords
- O/E
- Olf-1/EBF
- differentiation and maturation
- neurodevelopment
- olfactory gene regulation
- sensory neurons
- transcription factors
ASJC Scopus subject areas
- General Neuroscience