The changing scene of amyotrophic lateral sclerosis

Wim Robberecht, Thomas Philips

Research output: Contribution to journalReview articlepeer-review

Abstract

Several recent breakthroughs have provided notable insights into the pathogenesis of amyotrophic lateral sclerosis (ALS), with some even shifting our thinking about this neurodegenerative disease and raising the question as to whether this disorder is a proteinopathy, a ribonucleopathy or both. In addition, these breakthroughs have revealed mechanistic links between ALS and frontotemporal dementia, as well as between ALS and other neurodegenerative diseases, such as the cerebellar atrophies, myotonic dystrophy and inclusion body myositis. Here, we summarize the new findings in ALS research, discuss what they have taught us about this disease and examine issues that are still outstanding.

Original languageEnglish (US)
Pages (from-to)248-264
Number of pages17
JournalNature Reviews Neuroscience
Volume14
Issue number4
DOIs
StatePublished - Apr 1 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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