The changing face of head and neck cancer in the 21st century: The impact of hpv on the epidemiology and pathology of oral cancer

William H. Westra

Research output: Contribution to journalArticlepeer-review

Abstract

The longstanding notion that head and neck squamous cell carcinoma (HNSCC) is a uniform disease process is changing. Divergence in epidemiologic trends among HNSCCs arising in different anatomic subsites has introduced a view that HNSCC is a heterogeneous group. Analysis of molecular genetic changes discloses not just individual tumor differences, but also consistent large-scale differences that permit the recognition of important tumor subtypes. One recently recognized subtype is the human papillomavirus (HPV)-positive oropharyngeal carcinoma. HPV-positive oropharyngeal cancer now dominates the head and neck oncology landscape, and its escalating incidence is impacting on diagnostic, preventive and therapeutic practices.

Original languageEnglish (US)
Pages (from-to)78-81
Number of pages4
JournalHead and Neck Pathology
Volume3
Issue number1
DOIs
StatePublished - Mar 2009

Keywords

  • Head and neck squamous cell carcinoma
  • Human papillomavirus
  • In situ hybridization
  • Oral cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

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