The challenge of HIV-1 antiretroviral resistance in Africa in the era of HAART

Hakim Sendagire, Phillipa J. Easterbrook, Immaculate Nanka, Eric Arts, David Thomas, Steven J. Reynolds

Research output: Contribution to journalReview articlepeer-review

Abstract

Antiretroviral therapy programs in Africa are currently providing treatment for almost two million people. The long-term success of large scale antiretroviral therapy programs in sub-Saharan Africa remains uncertain because of the limited information currently available on rates of virologic failure and selection for drug-resistant variants in the different HIV subtypes. This article provides a comprehensive review of the published literature on the prevalence of primary and secondary HIV drug resistance with different subtypes and in various settings across sub-Saharan Africa.

Original languageEnglish (US)
Pages (from-to)59-70
Number of pages12
JournalAIDS Reviews
Volume11
Issue number2
StatePublished - 2009

Keywords

  • ART
  • Africa
  • Antiretroviral therapy
  • Genotypic
  • Phenotypic
  • Resistance
  • Subtypes

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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