The cerebroplacental Doppler ratio revisited

A. A. Baschat, U. Gembruch

Research output: Contribution to journalArticlepeer-review

298 Scopus citations


Objective: To evaluate the distribution of Doppler pulsatility index (PI) measurements of the umbilical and middle cerebral arteries in singleton fetuses of women with normal uterine artery blood flow and to construct reference ranges for the cerebroplacental PI Doppler ratio. Methods: The PI was determined in the mid-portion of the umbilical artery and the mid- or distal segment of the middle cerebral artery in 306 normal singleton fetuses. The cerebroplacental Doppler ratio (CPR) was determined from paired measurements. After determination of the best fit, reference ranges were constructed for each parameter against gestational age (GA). Results: The PI for the umbilical artery had a linear relationship with GA (umbilical artery PI = -0.0246 × GA + 1.7791, r2 = 0.4025, P < 0.001). The middle cerebral artery PI and the CPR both showed a quadratic relationship with GA (middle cerebral artery PI = -0.0058 × GA2 + 0.3335 × GA -2.7317, r2 = 0.2365, P < 0.01), (CPR = -0.0059 × GA2 + 0.383 × GA 4.0636, r2 = 0.2788, P < 0.001). Conclusion: The CPR is not constant throughout gestation. Reference ranges constructed by a standardized Doppler technique may he of benefit in the monitoring of high-risk pregnancies.

Original languageEnglish (US)
Pages (from-to)124-127
Number of pages4
JournalUltrasound in Obstetrics and Gynecology
Issue number2
StatePublished - Feb 1 2003
Externally publishedYes


  • Cerebral blood flow
  • Cerebroplacental ratio
  • Doppler ultrasound
  • Umbilical blood flow

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynecology


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