The “central vein sign” in inflammatory demyelination: The role of fibrillar collagen type I

Martina Absinta, Govind Nair, Maria Chiara G. Monaco, Dragan Maric, Nathanael J. Lee, Seung Kwon Ha, Nicholas J. Luciano, Pascal Sati, Steven Jacobson, Daniel S. Reich

Research output: Contribution to journalArticle

Abstract

Accumulating evidence corroborates the role of the “central vein sign” in the radiological diagnosis of multiple sclerosis (MS). Here, we report human magnetic resonance imaging (MRI) and corresponding pathological data that inflammation-dependent intracerebral remodeling of the vessel wall is directly associated with the prominence of intralesional veins on susceptibility-based MRI. In adult marmosets with experimental autoimmune encephalomyelitis, vessel-wall fibrosis was detected early in the demyelinating process, even in lesions <2 weeks old, though fibrosis was more evident after 6 weeks. Vascular remodeling consisted of both luminal enlargement and eccentric thickening of the perivascular space (fibrillar collagen type I deposition) and affected almost exclusively white matter, but not subpial cortical, lesions. The long-term effect of vessel remodeling in MS lesions is currently unknown, but it might potentially affect tissue repair. ANN NEUROL 2019;85:934–942.

Original languageEnglish (US)
Pages (from-to)934-942
Number of pages9
JournalAnnals of neurology
Volume85
Issue number6
DOIs
StatePublished - Jun 1 2019
Externally publishedYes

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Fibrillar Collagens
Demyelinating Diseases
Collagen Type I
Multiple Sclerosis
Veins
Fibrosis
Magnetic Resonance Imaging
Callithrix
Autoimmune Experimental Encephalomyelitis
Inflammation
White Matter
Vascular Remodeling

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Absinta, M., Nair, G., Monaco, M. C. G., Maric, D., Lee, N. J., Ha, S. K., ... Reich, D. S. (2019). The “central vein sign” in inflammatory demyelination: The role of fibrillar collagen type I. Annals of neurology, 85(6), 934-942. https://doi.org/10.1002/ana.25461

The “central vein sign” in inflammatory demyelination : The role of fibrillar collagen type I. / Absinta, Martina; Nair, Govind; Monaco, Maria Chiara G.; Maric, Dragan; Lee, Nathanael J.; Ha, Seung Kwon; Luciano, Nicholas J.; Sati, Pascal; Jacobson, Steven; Reich, Daniel S.

In: Annals of neurology, Vol. 85, No. 6, 01.06.2019, p. 934-942.

Research output: Contribution to journalArticle

Absinta, M, Nair, G, Monaco, MCG, Maric, D, Lee, NJ, Ha, SK, Luciano, NJ, Sati, P, Jacobson, S & Reich, DS 2019, 'The “central vein sign” in inflammatory demyelination: The role of fibrillar collagen type I', Annals of neurology, vol. 85, no. 6, pp. 934-942. https://doi.org/10.1002/ana.25461
Absinta, Martina ; Nair, Govind ; Monaco, Maria Chiara G. ; Maric, Dragan ; Lee, Nathanael J. ; Ha, Seung Kwon ; Luciano, Nicholas J. ; Sati, Pascal ; Jacobson, Steven ; Reich, Daniel S. / The “central vein sign” in inflammatory demyelination : The role of fibrillar collagen type I. In: Annals of neurology. 2019 ; Vol. 85, No. 6. pp. 934-942.
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