TY - JOUR
T1 - The central arterial burden of the metabolic syndrome is similar in men and women
T2 - The SardiNIA Study
AU - Scuteri, Angelo
AU - Najjar, Samer S.
AU - Orru', Marco
AU - Usala, Gianluca
AU - Piras, Maria Grazia
AU - Ferrucci, Luigi
AU - Cao, Antonio
AU - Schlessinger, David
AU - Uda, Manuela
AU - Lakatta, Edward G.
N1 - Funding Information:
We thank Monsignore Piseddu, Bishop of Ogliastra, the Mayors of Lanusei, Ilbono, Arzana, and Elini, the head of the local Public Health Unit ASL4, and the residents of the towns, for their volunteerism and cooperation. In addition, we are also grateful to the Mayor and the administration in Lanusei for providing and furnishing the clinic site. This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging (USA).
Funding Information:
The SardiNIA team was supported by Contract NO1-AG-1-2109 from the NIA.
PY - 2010/3
Y1 - 2010/3
N2 - Aims We evaluated whether specific clusters of metabolic syndrome (MetS) components differentially impact on arterial structure and function, and whether the impact is similar in men and in women.Methods and results Components of the MetS and arterial properties were assessed in 6148 subjects, aged 14-102 in a cluster of four towns in Sardinia, Italy. MetS was defined in accordance with the ATP III criteria. Age groups were classified as: <35, 35-49, 50-64, and ≥65 years. Systolic blood pressure (BP), diastolic BP, pulse pressure, common carotid artery (CCA) diameter, intima-media thickness, distensibility, strain, stiffness index, wall stress, and aortic pulse wave velocity were measured. Common carotid artery plaque was defined as focal encroachment of the arterial wall and CCA calcification as acoustic shadowing. In any age group, subjects with MetS presented thicker, stiffer or less distensible, and wider large arteries than controls. The arterial burden of MetS increased as the number of altered MetS components increased. However, not all MetS components were associated with the same changes in arterial properties. In fact, specific clusters of MetS components, i.e. any combination of altered glucose tolerance, elevated BP, and elevated triglycerides (with or without abdominal obesity), dramatically increased age-associated arterial changes. The impact of MetS on arterial function was similar in men and women.ConclusionMetS accelerates age-associated arterial changes, even in older persons. However, not all the clusters of MetS components render the same burden on arterial structure and function.
AB - Aims We evaluated whether specific clusters of metabolic syndrome (MetS) components differentially impact on arterial structure and function, and whether the impact is similar in men and in women.Methods and results Components of the MetS and arterial properties were assessed in 6148 subjects, aged 14-102 in a cluster of four towns in Sardinia, Italy. MetS was defined in accordance with the ATP III criteria. Age groups were classified as: <35, 35-49, 50-64, and ≥65 years. Systolic blood pressure (BP), diastolic BP, pulse pressure, common carotid artery (CCA) diameter, intima-media thickness, distensibility, strain, stiffness index, wall stress, and aortic pulse wave velocity were measured. Common carotid artery plaque was defined as focal encroachment of the arterial wall and CCA calcification as acoustic shadowing. In any age group, subjects with MetS presented thicker, stiffer or less distensible, and wider large arteries than controls. The arterial burden of MetS increased as the number of altered MetS components increased. However, not all MetS components were associated with the same changes in arterial properties. In fact, specific clusters of MetS components, i.e. any combination of altered glucose tolerance, elevated BP, and elevated triglycerides (with or without abdominal obesity), dramatically increased age-associated arterial changes. The impact of MetS on arterial function was similar in men and women.ConclusionMetS accelerates age-associated arterial changes, even in older persons. However, not all the clusters of MetS components render the same burden on arterial structure and function.
KW - Ageing
KW - Arterial stiffness
KW - Carotid IMT
KW - Gender
KW - Metabolic syndrome
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U2 - 10.1093/eurheartj/ehp491
DO - 10.1093/eurheartj/ehp491
M3 - Article
C2 - 19942601
AN - SCOPUS:77749292094
SN - 0195-668X
VL - 31
SP - 602
EP - 613
JO - European heart journal
JF - European heart journal
IS - 5
ER -