Injury to skin tissue elicits a repair response aimed at restoring epithelial continuity, which is essential to a normal skin barrier function. Skin keratinocytes at the wound margins are recruited for the re- epithelialization of the wound site. While the migration of keratinocytes occurs in the form of a stratified sheet, the relative contribution and ultimate fate of progenitor and differentiating keratinocytes during this vital process remain unclean. In addition to wound healing, this issue has important implications for our understanding of epidermal differentiation and, in particular, of commitment of progenitor keratinocytes to terminal differentiation. In this article we review the available evidence concerning the cellular mechanisms of keratinocyte migration into a wound site, and discuss the potential usefulness of the transgenic mouse technology to examine these issues in greater detail in vivo.
|Original language||English (US)|
|Number of pages||7|
|Journal||Cell Vision - Journal of Analytical Morphology|
|State||Published - Jan 1 1996|
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