The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides

T. M. Kristie, J. L. Pomerantz, T. C. Twomey, S. A. Parent, P. A. Sharp

Research output: Contribution to journalArticlepeer-review


The α/immediate early genes of herpes simplex virus are regulated by the specific assembly of a multiprotein enhancer complex containing the Oct-1 POU domain protein, the viral α-transinduction factor αTIF, (VP16, ICP25), and the C1 cellular factor. The C1 factor from mammalian cells is a heterogeneous but related set of polypeptides that interact directly with the α- transinduction factor to form a heteromeric protein complex. The isolation of cDNAs encoding the polypeptides of the C1 factor suggests that these proteins are proteolytic products of a novel precursor. The sequence of the amino termini of these polypeptide products indicate that the proteins are generated by site-specific cleavages within a reiterated 20-amino acid sequence. Although the C1 factor appears to be ubiquitously expressed, it is localized to subnuclear structures in specific cell types.

Original languageEnglish (US)
Pages (from-to)4387-4394
Number of pages8
JournalJournal of Biological Chemistry
Issue number9
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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