The cellular and molecular basis of direction selectivity of Aδ-LTMRs

Michael Rutlin, Cheng Ying Ho, Victoria E. Abraira, Colleen Cassidy, C. Jeffery Woodbury, David D. Ginty

Research output: Contribution to journalArticle

Abstract

The perception of touch, including the direction of stimulus movement across the skin, begins with activation of low-threshold mechanosensory neurons (LTMRs) that innervate the skin. Here, we show that murine Aδ-LTMRs are preferentially tuned to deflection of body hairs in the caudal-to-rostral direction. This tuning property is explained by the finding that Aδ-LTMR lanceolate endings around hair follicles are polarized; they are concentrated on the caudal (downward) side of each hair follicle. The neurotrophic factor BDNF is synthesized in epithelial cells on the caudal, but not rostral, side of hair follicles, in close proximity to Aδ-LTMR lanceolate endings, which express TrkB. Moreover, ablation of BDNF in hair follicle epithelial cells disrupts polarization of Aδ-LTMR lanceolate endings and results in randomization of Aδ-LTMR responses to hair deflection. Thus, BDNF-TrkB signaling directs polarization of Aδ-LTMR lanceolate endings, which underlies direction-selective responsiveness of Aδ-LTMRs to hair deflection. PaperClip

Original languageEnglish (US)
Pages (from-to)1640-1651
Number of pages12
JournalCell
Volume159
Issue number7
DOIs
StatePublished - Dec 18 2014

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Neurons
Hair Follicle
Brain-Derived Neurotrophic Factor
Hair
Skin
Epithelial Cells
Touch Perception
Polarization
Direction compound
Nerve Growth Factors
Random Allocation
Ablation
Tuning
Chemical activation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rutlin, M., Ho, C. Y., Abraira, V. E., Cassidy, C., Woodbury, C. J., & Ginty, D. D. (2014). The cellular and molecular basis of direction selectivity of Aδ-LTMRs. Cell, 159(7), 1640-1651. https://doi.org/10.1016/j.cell.2014.11.038

The cellular and molecular basis of direction selectivity of Aδ-LTMRs. / Rutlin, Michael; Ho, Cheng Ying; Abraira, Victoria E.; Cassidy, Colleen; Woodbury, C. Jeffery; Ginty, David D.

In: Cell, Vol. 159, No. 7, 18.12.2014, p. 1640-1651.

Research output: Contribution to journalArticle

Rutlin, M, Ho, CY, Abraira, VE, Cassidy, C, Woodbury, CJ & Ginty, DD 2014, 'The cellular and molecular basis of direction selectivity of Aδ-LTMRs', Cell, vol. 159, no. 7, pp. 1640-1651. https://doi.org/10.1016/j.cell.2014.11.038
Rutlin M, Ho CY, Abraira VE, Cassidy C, Woodbury CJ, Ginty DD. The cellular and molecular basis of direction selectivity of Aδ-LTMRs. Cell. 2014 Dec 18;159(7):1640-1651. https://doi.org/10.1016/j.cell.2014.11.038
Rutlin, Michael ; Ho, Cheng Ying ; Abraira, Victoria E. ; Cassidy, Colleen ; Woodbury, C. Jeffery ; Ginty, David D. / The cellular and molecular basis of direction selectivity of Aδ-LTMRs. In: Cell. 2014 ; Vol. 159, No. 7. pp. 1640-1651.
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