The cell biology of neuronal navigation

Hong Jun Song, Mu Ming Poo

Research output: Contribution to journalArticle

Abstract

Morphogenesis of the nervous system requires the directed migration of postmitotic neurons to designated locations in the nervous system and the guidance of axon growth cones to their synaptic targets. Evidence suggests that both forms of navigation depend on common guidance molecules, surface receptors and signal transduction pathways that link receptor activation to cytoskeletal reorganization. Future challenges remain not only in identifying all the components of the signalling pathways, but also in understanding how these pathways achieve signal amplification and adaptation-two essential cellular processes for neuronal navigation.

Original languageEnglish (US)
JournalNature Cell Biology
Volume3
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

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Nervous System
Cell Biology
Signal Transduction
Growth Cones
Morphogenesis
Neurons
Axon Guidance

ASJC Scopus subject areas

  • Cell Biology

Cite this

The cell biology of neuronal navigation. / Song, Hong Jun; Poo, Mu Ming.

In: Nature Cell Biology, Vol. 3, No. 3, 2001.

Research output: Contribution to journalArticle

Song, Hong Jun ; Poo, Mu Ming. / The cell biology of neuronal navigation. In: Nature Cell Biology. 2001 ; Vol. 3, No. 3.
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