The cell biology of neuronal navigation

Hong Jun Song, Mu Ming Poo

Research output: Contribution to journalArticlepeer-review

Abstract

Morphogenesis of the nervous system requires the directed migration of postmitotic neurons to designated locations in the nervous system and the guidance of axon growth cones to their synaptic targets. Evidence suggests that both forms of navigation depend on common guidance molecules, surface receptors and signal transduction pathways that link receptor activation to cytoskeletal reorganization. Future challenges remain not only in identifying all the components of the signalling pathways, but also in understanding how these pathways achieve signal amplification and adaptation-two essential cellular processes for neuronal navigation.

Original languageEnglish (US)
JournalNature Cell Biology
Volume3
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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