Abstract
While the CD28/B7 pathway has been shown to play an important costimulatory role in the response of T cells to conventional antigens, its role in superantigen-mediated T cell activation has not been as clear. In this report, we used CD4+ T cells from ovalbumin-specific αβ-TCR-transgenic mice (DO11.10) to compare the ability of this pathway to costimulate the response of primary T cells to conventional antigens and superantigens. We show that either the addition of anti-CD28 monoclonal antibody or presentation with a B7 transfected cell line enhances the proliferative and interleukin-2 secretion response of DO11.10 CD4+ cells to both the conventional antigen, ovalbumin peptide (OVA 323-339), and the superantigen SEB. This implies that CD28-mediated costimulation plays a role in the response of murine T cells to superantigens as well as to conventional antigens.
Original language | English (US) |
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Pages (from-to) | 306-312 |
Number of pages | 7 |
Journal | Cellular Immunology |
Volume | 157 |
Issue number | 1 |
DOIs | |
State | Published - Aug 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology