The Catecholamine Response to Multisystem Trauma

Paul D. Woolf, Joseph V. McDonald, David V. Feliciano, Mary M. Kelly, Diane Nichols, Christopher Cox

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the catecholamine response in two groups of patients with multisystem injuries according to the presence (group 1, N=124) or absence (group 2, N=82) of head injury. Markers of injury severity included the Injury Severity Score, the Glasgow Coma Scale, the need for intubation, admission hypotension, the amount of blood products and fluid expanders administered during the first 24 hours, and patient outcome. In group 1, higher norepinephrine levels always and epinephrine concentrations usually were associated with worsening indexes of injury severity. The best correlations were between the Injury Severity Score and the Glasgow Coma Scale and norepinephrine concentrations. In group 2, despite elevated catecholamine levels, such associations were seldom present. Thus, circulating catecholamine levels, especially norepinephrine levels, significantly correlated with the severity of injury in patients who had suffered multisystem injury, but only if the injury included the brain.

Original languageEnglish (US)
Pages (from-to)899-903
Number of pages5
JournalArchives of surgery
Volume127
Issue number8
DOIs
StatePublished - Aug 1992
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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