The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: Findings from a large German case-control and family-based sample

Vanessa Nieratschker, Josef Frank, Thomas W. Mühleisen, Jana Strohmaier, Jens R. Wendland, Johannes Schumacher, Jens Treutlein, René Breuer, Rami Abou Jamra, M. Mattheisen Manuel, Stefan Herms, Christine Schmäl, Wolfgang Maier, Markus M. Nöthen, Sven Cichon, Marcella Rietschel, Thomas G. Schulze

Research output: Contribution to journalArticle

Abstract

The aim of the present study was to investigate possible associations between schizophrenia and 13 SNP markers in COMT. No association was observed in 631 cases, 207 nuclear families, and 776 controls. A cognitive performance phenotype (Trail Marking Test) was available for a subgroup of the patients. No association was found between the 13 markers and this phenotype. Four clinically-defined subgroups (early age at onset, negative symptoms, family history of schizophrenia, and life-time major depressive episode) were also investigated. Associations were observed for 3 of these subgroups, although none withstood correction for multiple testing. COMT does not appear to be a risk factor for schizophrenia in this population.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalSchizophrenia Research
Volume122
Issue number1-3
DOIs
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • Catechol-O-Methyltransferase
  • Cognitive function
  • COMT
  • Polymorphism
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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  • Cite this

    Nieratschker, V., Frank, J., Mühleisen, T. W., Strohmaier, J., Wendland, J. R., Schumacher, J., Treutlein, J., Breuer, R., Jamra, R. A., Mattheisen Manuel, M., Herms, S., Schmäl, C., Maier, W., Nöthen, M. M., Cichon, S., Rietschel, M., & Schulze, T. G. (2010). The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: Findings from a large German case-control and family-based sample. Schizophrenia Research, 122(1-3), 24-30. https://doi.org/10.1016/j.schres.2010.06.018