The case for multiple opiate receptors

R. Suzanne Zukin, Stephen R. Zukin

Research output: Contribution to journalArticlepeer-review


As recently as ten years ago the opiate receptor was demonstrated biochemically for the first time and it was assumed that opiate drugs produced their psychotropic actions through a unique opiate receptor. Today compelling evidence from behavioral, pharmacological and biochemical studies indicates the existence of at least four receptor classes, μ, δ, κ and σ. The constellation of neuropharmacological actions of opiates as well as those of the three major classes of opioid peptides (β-endorphin, the enkephalins and dynorphin-related peptides) are now thought to occur by an interaction with a combination of these sites.

Original languageEnglish (US)
JournalTrends in Neurosciences
Issue number5
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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