The cardiovascular toll of stress

Daniel J. Brotman; Sherita H. Golden; Ilan S. Wittstein

doi:10.1016/S0140-6736(07)61305-1

The cardiovascular toll of stress

Daniel J. Brotman, Sherita H. Golden, Ilan S. Wittstein

School of Medicine

Research output: Contribution to journal › Review article › peer-review

462 Scopus citations

Abstract

Psychological stress elicits measurable changes in sympathetic-parasympathetic balance and the tone of the hypothalamic-pituitary-adrenal axis, which might negatively affect the cardiovascular system both acutely-by precipitating myocardial infarction, left-ventricular dysfunction, or dysrhythmia; and chronically-by accelerating the atherosclerotic process. We provide an overview of the association between stress and cardiovascular morbidity, discuss the mechanisms for this association, and address possible therapeutic implications.

Original language	English (US)
Pages (from-to)	1089-1100
Number of pages	12
Journal	Lancet
Volume	370
Issue number	9592
DOIs	https://doi.org/10.1016/S0140-6736(07)61305-1
State	Published - Sep 22 2007

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(07)61305-1

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abstract = "Psychological stress elicits measurable changes in sympathetic-parasympathetic balance and the tone of the hypothalamic-pituitary-adrenal axis, which might negatively affect the cardiovascular system both acutely-by precipitating myocardial infarction, left-ventricular dysfunction, or dysrhythmia; and chronically-by accelerating the atherosclerotic process. We provide an overview of the association between stress and cardiovascular morbidity, discuss the mechanisms for this association, and address possible therapeutic implications.",

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AU - Brotman, Daniel J.

AU - Golden, Sherita H.

AU - Wittstein, Ilan S.

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N2 - Psychological stress elicits measurable changes in sympathetic-parasympathetic balance and the tone of the hypothalamic-pituitary-adrenal axis, which might negatively affect the cardiovascular system both acutely-by precipitating myocardial infarction, left-ventricular dysfunction, or dysrhythmia; and chronically-by accelerating the atherosclerotic process. We provide an overview of the association between stress and cardiovascular morbidity, discuss the mechanisms for this association, and address possible therapeutic implications.

AB - Psychological stress elicits measurable changes in sympathetic-parasympathetic balance and the tone of the hypothalamic-pituitary-adrenal axis, which might negatively affect the cardiovascular system both acutely-by precipitating myocardial infarction, left-ventricular dysfunction, or dysrhythmia; and chronically-by accelerating the atherosclerotic process. We provide an overview of the association between stress and cardiovascular morbidity, discuss the mechanisms for this association, and address possible therapeutic implications.

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JO - Lancet

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The cardiovascular toll of stress

Abstract

ASJC Scopus subject areas

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