TY - JOUR
T1 - The capsular polysaccharide and lipopolysaccharide structures of two carbapenem resistant Klebsiella pneumoniae outbreak isolates
AU - Kubler-Kielb, Joanna
AU - Vinogradov, Evgeny
AU - Ng, Weng Ian
AU - MacZynska, Beata
AU - Junka, Adam
AU - Bartoszewicz, Marzenna
AU - Zelazny, Adrian
AU - Bennett, John
AU - Schneerson, Rachel
N1 - Funding Information:
Authors thank Prof. A. Przondo-Mordarska and Prof. A. Gamian for help in this project. This work was partially supported by the intramural programs of NICHD , NIAID and Clinical Center, National Institutes of Health, Bethesda, MD.
PY - 2013
Y1 - 2013
N2 - Carbapenem resistant Klebsiella pneumoniae (CRKP) are isolated with increasing frequency, especially from immunocompromized patients. The capsular polysaccharide (CPS) types of CPKP were not determined. Investigation of two CRKP isolates from a 2011 outbreak at the Clinical Center, the National Institutes of Health, identified a new capsular type shared by the two isolates, similar to K. pneumonia K19 and K34 but structurally different than any published K. pneumoniae CPS repeating unit: The LPS of the two isolates was found to have no O-specific polysaccharide and the chemical structure of the core oligosaccharides agreed with the published data. If this structure type will be prevalent among CPKP isolates, our findings could facilitate rapid diagnosis and help to develop new therapeutic solutions to this antibiotic resistant pathogen.
AB - Carbapenem resistant Klebsiella pneumoniae (CRKP) are isolated with increasing frequency, especially from immunocompromized patients. The capsular polysaccharide (CPS) types of CPKP were not determined. Investigation of two CRKP isolates from a 2011 outbreak at the Clinical Center, the National Institutes of Health, identified a new capsular type shared by the two isolates, similar to K. pneumonia K19 and K34 but structurally different than any published K. pneumoniae CPS repeating unit: The LPS of the two isolates was found to have no O-specific polysaccharide and the chemical structure of the core oligosaccharides agreed with the published data. If this structure type will be prevalent among CPKP isolates, our findings could facilitate rapid diagnosis and help to develop new therapeutic solutions to this antibiotic resistant pathogen.
KW - CRKP
KW - Capsular polysaccharide
KW - KPC
KW - LPS
KW - Structure
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U2 - 10.1016/j.carres.2012.12.018
DO - 10.1016/j.carres.2012.12.018
M3 - Article
C2 - 23360863
AN - SCOPUS:84872815761
SN - 0008-6215
VL - 369
SP - 6
EP - 9
JO - Carbohydrate Research
JF - Carbohydrate Research
ER -