The capsular dynamics of Cryptococcus neoformans

Diane McFadden; Oscar Zaragoza; Arturo Casadevall

doi:10.1016/j.tim.2006.09.003

The capsular dynamics of Cryptococcus neoformans

Diane McFadden, Oscar Zaragoza, Arturo Casadevall

Research output: Contribution to journal › Review article › peer-review

Abstract

Cryptococcus neoformans is a soil-dwelling fungus that causes life-threatening illness in immunocompromised individuals and latently infects many healthy individuals. C. neoformans, unlike other human pathogenic fungi, is surrounded by a polysaccharide capsule that is essential for survival and enables C. neoformans to thwart the mammalian immune system. The capsule is a dynamic structure that undergoes changes in size and rearranges during budding. Here, the latest information and unresolved questions regarding capsule synthesis, structure, assembly, growth and rearrangements are discussed along with the concept that self-assembly is important in capsular dynamics.

Original language	English (US)
Pages (from-to)	497-505
Number of pages	9
Journal	Trends in Microbiology
Volume	14
Issue number	11
DOIs	https://doi.org/10.1016/j.tim.2006.09.003
State	Published - Nov 1 2006
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

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AB - Cryptococcus neoformans is a soil-dwelling fungus that causes life-threatening illness in immunocompromised individuals and latently infects many healthy individuals. C. neoformans, unlike other human pathogenic fungi, is surrounded by a polysaccharide capsule that is essential for survival and enables C. neoformans to thwart the mammalian immune system. The capsule is a dynamic structure that undergoes changes in size and rearranges during budding. Here, the latest information and unresolved questions regarding capsule synthesis, structure, assembly, growth and rearrangements are discussed along with the concept that self-assembly is important in capsular dynamics.

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