TY - JOUR
T1 - The capsular dynamics of Cryptococcus neoformans
AU - McFadden, Diane
AU - Zaragoza, Oscar
AU - Casadevall, Arturo
N1 - Funding Information:
We gratefully acknowledge funding through the NIH to A.C. (AI33774, AI33142 and HL59842), support from the Burroughs Wellcome Fund through the Life Sciences Research Foundation to D.M., and grants MPY 1025/06 (Programa Ramon y Cajal, Ministerio de Educacion y Ciencia) and MPY 1181/06 (Instituto de Salud Carlos III) to O.Z.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006/11
Y1 - 2006/11
N2 - Cryptococcus neoformans is a soil-dwelling fungus that causes life-threatening illness in immunocompromised individuals and latently infects many healthy individuals. C. neoformans, unlike other human pathogenic fungi, is surrounded by a polysaccharide capsule that is essential for survival and enables C. neoformans to thwart the mammalian immune system. The capsule is a dynamic structure that undergoes changes in size and rearranges during budding. Here, the latest information and unresolved questions regarding capsule synthesis, structure, assembly, growth and rearrangements are discussed along with the concept that self-assembly is important in capsular dynamics.
AB - Cryptococcus neoformans is a soil-dwelling fungus that causes life-threatening illness in immunocompromised individuals and latently infects many healthy individuals. C. neoformans, unlike other human pathogenic fungi, is surrounded by a polysaccharide capsule that is essential for survival and enables C. neoformans to thwart the mammalian immune system. The capsule is a dynamic structure that undergoes changes in size and rearranges during budding. Here, the latest information and unresolved questions regarding capsule synthesis, structure, assembly, growth and rearrangements are discussed along with the concept that self-assembly is important in capsular dynamics.
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U2 - 10.1016/j.tim.2006.09.003
DO - 10.1016/j.tim.2006.09.003
M3 - Review article
C2 - 16996739
AN - SCOPUS:33749822152
VL - 14
SP - 497
EP - 505
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 11
ER -