The capactins, a class of proteins that cap the ends of actin filaments.

S. Lin, D. H. Cribbs, J. A. Wilkins, J. F. Casella, W. W. Magargal, D. C. Lin

Research output: Contribution to journalArticlepeer-review

Abstract

A number of proteins that bind specifically to the barbed ends of actin filaments in a cytochalasin-like manner have been purified to various degrees from a variety of muscle and non-muscle cells and tissues. Preliminary evidence also indicates that proteins that interact with the pointed ends of filaments are present in skeletal muscle. Because of their ability to cap one or the other end of an actin filament, we have designated this class of proteins as the 'capactins'. On the basis of their effect on actin filament assembly and interaction in vitro, we propose that the capactins play important roles in cellular regulation of actin-based cytoskeletal and contractile functions. Our finding that the disappearance of actin filament bundles in virally transformed fibroblasts can be correlated with an increase in capactin activity in the extracts of these cells is consistent with this hypothesis.

Original languageEnglish (US)
Pages (from-to)263-273
Number of pages11
JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume299
Issue number1095
DOIs
StatePublished - Nov 4 1982
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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