The cancer stem cell phenotype: You can't win until you learn how to lose it

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer stem cells and their relatively differentiated progenitors coexist in dynamic equilibrium and are subject to bidirectional conversion. We recently showed that reprogramming transcription factors induce glioblastoma cells to become stem-like and tumor propagating via a mechanism involving changes in global DNA methylation and downregulation of miRNAs.

Original languageEnglish (US)
Article numbere989760
JournalMolecular and Cellular Oncology
Volume2
Issue number3
DOIs
StatePublished - Jul 3 2015

Keywords

  • DNA methylation
  • cancer stem cell
  • miRNAs
  • reprogramming transcription factors
  • tumorigenesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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