The cancer epigenome - Components and functional correlates

Angela H. Ting, Kelly M. McGarvey, Stephen B. Baylin

Research output: Contribution to journalReview articlepeer-review

Abstract

It is increasingly apparent that cancer development not only depends on genetic alterations but on an abnormal cellular memory, or epigenetic changes, which convey heritable gene expression patterns critical for neoplastic initiation and progression. These aberrant epigenetic mechanisms are manifest in both global changes in chromatin packaging and in localized gene promoter changes that influence the transcription of genes important to the cancer process. An exciting emerging theme is that an understanding of stem cell chromatin control of gene expression, including relationships between histone modifications and DNA methylation, may hold a key to understanding the origins of cancer epigenetic changes. This possibility, coupled with the reversible nature of epigenetics, has enormous significance for the prevention and control of cancer.

Original languageEnglish (US)
Pages (from-to)3215-3231
Number of pages17
JournalGenes and Development
Volume20
Issue number23
DOIs
StatePublished - Dec 1 2006

Keywords

  • Cancer
  • Cancer stem cell
  • Chromatin modification
  • DNA methylation
  • Epigenetics

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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