The C523A β2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans

John J. Lima, Janet T. Holbrook, Jianwei Wang, James E. Sylvester, Kathryn V. Blake, Malcolm N. Blumenthal, Mario Castro, Nicholas Hanania, Robert Wise

Research output: Contribution to journalArticle

Abstract

Our goal was to explore associations between β2 adrenergic receptor polymorphisms and markers of asthma severity in African American and Caucasian patients with asthma. Polymorphisms at loci -1023, -654, -47, 46, 79, 491, and 523 were genotyped and haplotypes were imputed in 143 African Americans and 336 Caucasians. C523A genotype associated with percentage of African Americans (but not of Caucasians) having an asthma exacerbation: AA, AC, and CC genotypes were 17, 29, and 40%, respectively ( p = 0.018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans.

Original languageEnglish (US)
Pages (from-to)185-191
Number of pages7
JournalJournal of Asthma
Volume43
Issue number3
DOIs
StatePublished - Jun 20 2006

Keywords

  • Asthma severity
  • Polymorphisms
  • Race
  • β adrenergic receptor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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