The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations

F. Crawford, Daniele Daniele Fallin, Z. Suo, L. Abdullah, M. Gold, A. Gauntlett, R. Duara, M. Mullan

Research output: Contribution to journalArticle

Abstract

The K variant of the butyrylcholinesterase gene (BChE) was recently found to occur at an increased frequency in a late onset Alzheimer's disease (AD) population, specifically in individuals carrying the ε4 allele of the apolipoprotein E (APOE) gene. This suggested synergy between these two genes resulting in an increased risk of late-onset AD. We have genotyped 62 community-based and 329 clinic-based AD cases, and 201 community-based controls at BChE and APOE and find no independent association between BChE and AD nor interaction with APOE in risk for AD in either our clinic or community-based samples.

Original languageEnglish (US)
Pages (from-to)115-118
Number of pages4
JournalNeuroscience Letters
Volume249
Issue number2-3
DOIs
StatePublished - Jun 19 1998
Externally publishedYes

Fingerprint

Butyrylcholinesterase
Alzheimer Disease
Population
Genes
Apolipoproteins E
Apolipoprotein E4
Alleles

Keywords

  • Alzheimer's Disease
  • Apolipoprotein E
  • Butyrylcholinesterase
  • Genetic association
  • K variant

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations. / Crawford, F.; Fallin, Daniele Daniele; Suo, Z.; Abdullah, L.; Gold, M.; Gauntlett, A.; Duara, R.; Mullan, M.

In: Neuroscience Letters, Vol. 249, No. 2-3, 19.06.1998, p. 115-118.

Research output: Contribution to journalArticle

Crawford, F. ; Fallin, Daniele Daniele ; Suo, Z. ; Abdullah, L. ; Gold, M. ; Gauntlett, A. ; Duara, R. ; Mullan, M. / The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations. In: Neuroscience Letters. 1998 ; Vol. 249, No. 2-3. pp. 115-118.
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