TY - JOUR
T1 - The burden of Staphylococcus aureus among Native Americans on the Navajo Nation
AU - Sutcliffe, Catherine G.
AU - Grant, Lindsay R.
AU - Reid, Angelina
AU - Douglass, Grace K.
AU - Weatherholtz, Robert C.
AU - Hubler, Robin
AU - Quintana, Alvaro
AU - Reid, Raymond
AU - Yazzie, Del
AU - Santosham, Mathuram
AU - O’Brien, Katherine L.
AU - Hammitt, Laura L.
N1 - Funding Information:
This work was supported through a Clinical Research Collaboration award from Pfizer Inc. to LLH (protocol number: 1605050000 to LLH). Authors RH and AQ, who contributed to the design of the study and review of the manuscript, are employees of Pfizer. The funder did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. Disclaimer: The opinions expressed are those of the authors and do not necessarily reflect the views of Pfizer Inc.
Publisher Copyright:
© This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
PY - 2019/3
Y1 - 2019/3
N2 - Introduction Native Americans in the southwestern United States have a higher risk for many infectious diseases and may be at higher risk for Staphylococcus aureus due to the high prevalence of risk factors for S. aureus. Recent data on invasive S. aureus infections among Native Americans are limited. Methods Active population- and laboratory-based surveillance was conducted in 2016–2017 on the Navajo Nation to document the rate of invasive S. aureus. A case of invasive S.aureus infection was defined as a Native American individual with S. aureus isolated from a normally sterile body site whose reported community of residence was on or around the Navajo Nation. Results One hundred and fifty-nine cases of invasive S. aureus from 152 individuals were identified. The median age of cases was 56.3 years and 35% were female. Thirty-five percent of cases had community-acquired infections. Ninety-three percent of cases had underlying medical conditions, including diabetes (60%) and obesity (42%), 28% of cases had a documented prior S. aureus infection, and 33% were infected with methicillin-resistant S. aureus. The annual incidence of invasive S. aureus and of invasive methicillin-resistant S. aureus was 64.9/100,000 persons and 21.2/100,000 persons, respectively. Conclusions This community has a high burden of invasive S. aureus infections. Further research is needed to identify prevention strategies and opportunities for intervention.
AB - Introduction Native Americans in the southwestern United States have a higher risk for many infectious diseases and may be at higher risk for Staphylococcus aureus due to the high prevalence of risk factors for S. aureus. Recent data on invasive S. aureus infections among Native Americans are limited. Methods Active population- and laboratory-based surveillance was conducted in 2016–2017 on the Navajo Nation to document the rate of invasive S. aureus. A case of invasive S.aureus infection was defined as a Native American individual with S. aureus isolated from a normally sterile body site whose reported community of residence was on or around the Navajo Nation. Results One hundred and fifty-nine cases of invasive S. aureus from 152 individuals were identified. The median age of cases was 56.3 years and 35% were female. Thirty-five percent of cases had community-acquired infections. Ninety-three percent of cases had underlying medical conditions, including diabetes (60%) and obesity (42%), 28% of cases had a documented prior S. aureus infection, and 33% were infected with methicillin-resistant S. aureus. The annual incidence of invasive S. aureus and of invasive methicillin-resistant S. aureus was 64.9/100,000 persons and 21.2/100,000 persons, respectively. Conclusions This community has a high burden of invasive S. aureus infections. Further research is needed to identify prevention strategies and opportunities for intervention.
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U2 - 10.1371/journal.pone.0213207
DO - 10.1371/journal.pone.0213207
M3 - Article
C2 - 30835749
AN - SCOPUS:85062631213
SN - 1932-6203
VL - 14
JO - PloS one
JF - PloS one
IS - 3
M1 - e0213207
ER -