@article{1f3ba0917b71402bb6823268b5d33da1,
title = "The building blocks of successful translation of proteomics to the clinic",
abstract = "Recently, the first two multiplexed tests using selective reaction monitoring (SRM-MS) mass spectrometry have entered clinical practice. Despite different areas of indication, risk stratification in lung cancer and preterm birth, they share multiple steps in their development strategies. Here we review these strategies and their implications for successful translation of biomarkers to clinical practice. We believe that the identification of blood protein panels for the identification of disease phenotypes is now a reproducible and standard (albeit complex) process.",
author = "Paul Kearney and Boniface, {J. Jay} and Price, {Nathan D.} and Leroy Hood",
note = "Funding Information: We would like to acknowledge the efforts of the clinical, laboratory and R&D teams at Integrated Diagnostics and Sera Prognostics. For disclosure, PK holds shares in Integrated Diagnostics and Sera Prognostics, is an employee of Integrated Diagnostics and a consultant to Sera Prognostics. JB is an employee of Sera Prognostics and holds shares in the company. LH was a co-founder of Integrated Diagnostics and holds stock in the company. NDP is a consultant to Sera Prognostics. This work was supported by NIH Center for Systems Biology P50GM076547 (LH), DoD grant W911NF-16-2-0015 (LH), NIH R01HD091527 (NDP) and NIH R01CA200859 (NDP). Funding Information: We would like to acknowledge the efforts of the clinical, laboratory and R&D teams at Integrated Diagnostics and Sera Prognostics. For disclosure, PK holds shares in Integrated Diagnostics and Sera Prognostics, is an employee of Integrated Diagnostics and a consultant to Sera Prognostics. JB is an employee of Sera Prognostics and holds shares in the company. LH was a co-founder of Integrated Diagnostics and holds stock in the company. NDP is a consultant to Sera Prognostics. This work was supported by NIH Center for Systems Biology P50GM076547 (LH), DoD grant W911NF-16-2-0015 (LH), NIH R01HD091527 (NDP) and NIH R01CA200859 (NDP). Publisher Copyright: {\textcopyright} 2017",
year = "2018",
month = jun,
doi = "10.1016/j.copbio.2017.12.011",
language = "English (US)",
volume = "51",
pages = "123--129",
journal = "Current Opinion in Biotechnology",
issn = "0958-1669",
publisher = "Elsevier Limited",
}