The building blocks of successful translation of proteomics to the clinic

Paul Kearney; J. Jay Boniface; Nathan D. Price; Leroy Hood

doi:10.1016/j.copbio.2017.12.011

The building blocks of successful translation of proteomics to the clinic

Paul Kearney, J. Jay Boniface, Nathan D. Price, Leroy Hood

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Recently, the first two multiplexed tests using selective reaction monitoring (SRM-MS) mass spectrometry have entered clinical practice. Despite different areas of indication, risk stratification in lung cancer and preterm birth, they share multiple steps in their development strategies. Here we review these strategies and their implications for successful translation of biomarkers to clinical practice. We believe that the identification of blood protein panels for the identification of disease phenotypes is now a reproducible and standard (albeit complex) process.

Original language	English (US)
Pages (from-to)	123-129
Number of pages	7
Journal	Current Opinion in Biotechnology
Volume	51
DOIs	https://doi.org/10.1016/j.copbio.2017.12.011
State	Published - Jun 2018
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

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10.1016/j.copbio.2017.12.011

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AU - Boniface, J. Jay

AU - Price, Nathan D.

AU - Hood, Leroy

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AB - Recently, the first two multiplexed tests using selective reaction monitoring (SRM-MS) mass spectrometry have entered clinical practice. Despite different areas of indication, risk stratification in lung cancer and preterm birth, they share multiple steps in their development strategies. Here we review these strategies and their implications for successful translation of biomarkers to clinical practice. We believe that the identification of blood protein panels for the identification of disease phenotypes is now a reproducible and standard (albeit complex) process.

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The building blocks of successful translation of proteomics to the clinic

Abstract

ASJC Scopus subject areas

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