The Brown Longitudinal Obsessive Compulsive Study: Clinical features and symptoms of the sample at intake

Anthony Pinto, Maria C. Mancebo, Jane L. Eisen, Maria E. Pagano, Steve A. Rasmussen

Research output: Contribution to journalArticle

Abstract

Objective: This article describes the method and intake findings of the Brown Longitudinal Obsessive Compulsive Study, the first comprehensive prospective investigation of the naturalistic course of obsessive-compulsive disorder (OCD) in a large clinical sample using longitudinal research methodology. Method: Intake data, collected between June 2001 and October 2004, are presented for 293 adult participants in a prospective, naturalistic study of OCD. Participants had a primary diagnosis of DSM-IV OCD and had sought treatment for the disorder. Results: Our findings indicate that OCD typically has a gradual onset and a continuous course regardless of age at onset. There is a substantial lag between the onset of the disorder and initiation of treatment. OCD, which almost always coexists with other psychiatric symptoms, leads to serious social and occupational impairment. Compared with participants with late-onset OCD, early-onset participants had higher rates of lifetime panic disorder, eating disorders, and obsessive-compulsive personality disorder. The groups also differed on the types of obsessive-compulsive symptoms that were first noticed, as well as on rates of current obsessions and compulsions. Conclusion: The demographics, clinical characteristics, comorbidity rates, and symptom presentation of the sample are consistent with those reported for cross-sectional studies of OCD, including the DSM-IV Field Trial. The current sample has a number of advantages over previously collected prospective samples of OCD in that it is large, diagnostically well characterized, recruited from multiple settings, and treatment seeking. This unique data set will contribute to the identification of meaningful phenotypes in OCD based on stability of symptom dimensions, prospective course patterns, and treatment response.

Original languageEnglish (US)
Pages (from-to)703-711
Number of pages9
JournalJournal of Clinical Psychiatry
Volume67
Issue number5
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

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Obsessive-Compulsive Disorder
Compulsive Personality Disorder
Diagnostic and Statistical Manual of Mental Disorders
Clinical Studies
Obsessive Behavior
Panic Disorder
Therapeutics
Age of Onset
Psychiatry
Comorbidity
Research Design
Cross-Sectional Studies
Demography
Prospective Studies
Phenotype

ASJC Scopus subject areas

  • Psychiatry and Mental health

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The Brown Longitudinal Obsessive Compulsive Study : Clinical features and symptoms of the sample at intake. / Pinto, Anthony; Mancebo, Maria C.; Eisen, Jane L.; Pagano, Maria E.; Rasmussen, Steve A.

In: Journal of Clinical Psychiatry, Vol. 67, No. 5, 01.01.2006, p. 703-711.

Research output: Contribution to journalArticle

Pinto, Anthony ; Mancebo, Maria C. ; Eisen, Jane L. ; Pagano, Maria E. ; Rasmussen, Steve A. / The Brown Longitudinal Obsessive Compulsive Study : Clinical features and symptoms of the sample at intake. In: Journal of Clinical Psychiatry. 2006 ; Vol. 67, No. 5. pp. 703-711.
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