The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology

Lukas Pezawas; Beth A. Verchinski; Venkata S. Mattay; Joseph H. Callicott; Bhaskar S. Kolachana; Richard E. Straub; Michael F. Egan; Andreas Meyer-Lindenberg; Daniel R. Weinberger

doi:10.1523/JNEUROSCI.2680-04.2004

The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology

Lukas Pezawas, Beth A. Verchinski, Venkata S. Mattay, Joseph H. Callicott, Bhaskar S. Kolachana, Richard E. Straub, Michael F. Egan, Andreas Meyer-Lindenberg, Daniel R. Weinberger

Research output: Contribution to journal › Article › peer-review

708 Scopus citations

Abstract

A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

Original language	English (US)
Pages (from-to)	10099-10102
Number of pages	4
Journal	Journal of Neuroscience
Volume	24
Issue number	45
DOIs	https://doi.org/10.1523/JNEUROSCI.2680-04.2004
State	Published - Nov 10 2004
Externally published	Yes

Keywords

Alzheimer
BDNF
Down syndrome
Gene
Huntington
Imaging genomics
Memory
Morphometry
Neurotrophic
Schizophrenia
VBM
Voxel-based

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1523/JNEUROSCI.2680-04.2004

Cite this

@article{2c6d31cb925d4309bc6ca6c778adb21c,

title = "The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology",

abstract = "A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.",

keywords = "Alzheimer, BDNF, Down syndrome, Gene, Huntington, Imaging genomics, Memory, Morphometry, Neurotrophic, Schizophrenia, VBM, Voxel-based",

author = "Lukas Pezawas and Verchinski, {Beth A.} and Mattay, {Venkata S.} and Callicott, {Joseph H.} and Kolachana, {Bhaskar S.} and Straub, {Richard E.} and Egan, {Michael F.} and Andreas Meyer-Lindenberg and Weinberger, {Daniel R.}",

year = "2004",

month = nov,

day = "10",

doi = "10.1523/JNEUROSCI.2680-04.2004",

language = "English (US)",

volume = "24",

pages = "10099--10102",

journal = "Journal of Neuroscience",

issn = "0270-6474",

publisher = "Society for Neuroscience",

number = "45",

}

TY - JOUR

T1 - The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology

AU - Pezawas, Lukas

AU - Verchinski, Beth A.

AU - Mattay, Venkata S.

AU - Callicott, Joseph H.

AU - Kolachana, Bhaskar S.

AU - Straub, Richard E.

AU - Egan, Michael F.

AU - Meyer-Lindenberg, Andreas

AU - Weinberger, Daniel R.

PY - 2004/11/10

Y1 - 2004/11/10

N2 - A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

AB - A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

KW - Alzheimer

KW - BDNF

KW - Down syndrome

KW - Gene

KW - Huntington

KW - Imaging genomics

KW - Memory

KW - Morphometry

KW - Neurotrophic

KW - Schizophrenia

KW - VBM

KW - Voxel-based

UR - http://www.scopus.com/inward/record.url?scp=8544249878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8544249878&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.2680-04.2004

DO - 10.1523/JNEUROSCI.2680-04.2004

M3 - Article

C2 - 15537879

AN - SCOPUS:8544249878

SN - 0270-6474

VL - 24

SP - 10099

EP - 10102

JO - Journal of Neuroscience

JF - Journal of Neuroscience

IS - 45

ER -

The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this