TY - JOUR
T1 - The bone marrow stroma in hematological neoplasms-a guilty bystander
AU - Tripodo, Claudio
AU - Sangaletti, Sabina
AU - Piccaluga, Pier P.
AU - Prakash, Sonam
AU - Franco, Giovanni
AU - Borrello, Ivan
AU - Orazi, Attilio
AU - Colombo, Mario P.
AU - Pileri, Stefano A.
PY - 2011/8
Y1 - 2011/8
N2 - In the setting of hematological neoplasms, changes in the bone marrow (BM) stroma might arise from pressure exerted by the neoplastic clone in shaping a supportive microenvironment, or from chronic perturbation of the BM homeostasis. Under such conditions, alterations in the composition of the BM stroma can be profound, and could emerge as relevant prognostic factors. In this Review, we delineate the multifaceted contribution of the BM stroma to the pathobiology of several hematological neoplasms, and discuss the impact of stromal modifications on the natural course of these diseases. Specifically, we highlight the involvement of BM stromal components in lymphoid and myeloid malignancies, and present the most relevant processes responsible for remodeling the BM stroma. The role of bystander BM stromal elements in the setting of hematological neoplasms is discussed, strengthening the rationale for treatment strategies that target the BM stroma.
AB - In the setting of hematological neoplasms, changes in the bone marrow (BM) stroma might arise from pressure exerted by the neoplastic clone in shaping a supportive microenvironment, or from chronic perturbation of the BM homeostasis. Under such conditions, alterations in the composition of the BM stroma can be profound, and could emerge as relevant prognostic factors. In this Review, we delineate the multifaceted contribution of the BM stroma to the pathobiology of several hematological neoplasms, and discuss the impact of stromal modifications on the natural course of these diseases. Specifically, we highlight the involvement of BM stromal components in lymphoid and myeloid malignancies, and present the most relevant processes responsible for remodeling the BM stroma. The role of bystander BM stromal elements in the setting of hematological neoplasms is discussed, strengthening the rationale for treatment strategies that target the BM stroma.
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U2 - 10.1038/nrclinonc.2011.31
DO - 10.1038/nrclinonc.2011.31
M3 - Review article
C2 - 21448151
AN - SCOPUS:79961026116
SN - 1759-4774
VL - 8
SP - 456
EP - 466
JO - Nature Reviews Clinical Oncology
JF - Nature Reviews Clinical Oncology
IS - 8
ER -