Osteomyelitis causes an inflammatory reaction within the bone marrow early in its course, suggesting that bone marrow imaging with Tc-sulfurcolloid could be used for early detection of the disease. To test this hypothesis, 11 rabbits were inoculated with Staphylococcus aureus, 7 adults in the bone marrow and 4 immature rabbits in the epiphyseal plate. Six rabbits developed osteomyelitis by radiographic and pathologic criteria. Each demonstrated a marked decrease in reticuloendothelial function in the area of osteomyelitis, 4-11 days before radiographic changes were noted. The bone marrow scan was normal in septic arthritis, which was present in some animals before osteomyelitis became evident. These findings suggest that the bone marrow scan is a potentially useful study in early detection of osteomyelitis.
- Bone marrow scan
- Septic arthritis
- Staphylococcus aureus
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging