The BOLERO-2 trial: The addition of everolimus to exemestane in the treatment of postmenopausal hormone receptor-positive advanced breast cancer

Julia A. Beaver, Ben H. Park

Research output: Contribution to journalArticlepeer-review

Abstract

The combination of the mTOR inhibitor everolimus with the aromatase inhibitor exemestane was evaluated in the randomized Phase III BOLERO-2 trial. Research has indicated that aberrant signaling through the mTOR pathway is associated with resistance to endocrine therapies. The BOLERO-2 trial examined the effects on progression-free survival of the addition of everolimus to exemestane in a patient population of postmenopausal, hormone receptor-positive, advanced breast cancer. At the interim analysis, the median progression-free survival assessed by local investigators was 6.9 months for everolimus plus exemestane versus 2.8 months for placebo plus exemestane (hazard ratio: 0.43; p < 0.001), and by central assessment was 10.6 versus 4.1 months, respectively (hazard ratio: 0.36; p < 0.001). The everolimus plus exemestane arm showed greater number of grade 3 and 4 adverse events. This study suggests that the addition of everolimus to exemestane is a potential viable treatment option for this patient population.

Original languageEnglish (US)
Pages (from-to)651-657
Number of pages7
JournalFuture Oncology
Volume8
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • BOLERO-2
  • advanced breast cancer
  • endocrine resistance
  • everolimus
  • exemestane
  • hormone receptor-positive
  • mTOR inhibitor
  • postmenopausal

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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