The blood‐brain barrier is impermeable to metrizamide

Albert Gjedde

Research output: Contribution to journalArticlepeer-review

Abstract

The X‐ray contrast material metrizamide is a glucose analog, related to 2‐deoxy‐D‐glucose. The cerebral capillary endothelium, or blood‐brain barrier, is completely impermeable to this compound. It is unlikely, therefore, that metrizamide pass any cell membranes. Since the affinity for rat brain hexokinase is three orders of magnitude below that of Dglucose, it is equally unlikely that metrizamide attain intracellular concentrations in brain sufficient to inhibit glucose phosphorylation.

Original languageEnglish (US)
Pages (from-to)392-395
Number of pages4
JournalActa Neurologica Scandinavica
Volume66
Issue number3
DOIs
StatePublished - Sep 1982

Keywords

  • Amipaque®
  • X‐ray contrast materials
  • blood‐brain barrier
  • metrizamide

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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