Abstract
The X‐ray contrast material metrizamide is a glucose analog, related to 2‐deoxy‐D‐glucose. The cerebral capillary endothelium, or blood‐brain barrier, is completely impermeable to this compound. It is unlikely, therefore, that metrizamide pass any cell membranes. Since the affinity for rat brain hexokinase is three orders of magnitude below that of Dglucose, it is equally unlikely that metrizamide attain intracellular concentrations in brain sufficient to inhibit glucose phosphorylation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 392-395 |
| Number of pages | 4 |
| Journal | Acta Neurologica Scandinavica |
| Volume | 66 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1982 |
| Externally published | Yes |
Keywords
- Amipaque®
- X‐ray contrast materials
- blood‐brain barrier
- metrizamide
ASJC Scopus subject areas
- Neurology
- Clinical Neurology