The blood-brain barrier is impermeable to metrizamide

A. Gjedde

Research output: Contribution to journalArticle

Abstract

The X-ray contrast material metrizamide is a glucose analog, related to 2-deoxy-D-glucose. The cerebral capillary endothelium, or blood-brain barrier, is completely impermeable to this compound. It is unlikely, therefore, that metrizamide passes any cell membranes. Since the affinity for rat brain hexokinase is three orders of magnitude below that of D-glucose, it is equally unlikely that metrizamide attains intracellular concentrations in brain sufficient to inhibit glucose phosphorylation.

Original languageEnglish (US)
Pages (from-to)392-395
Number of pages4
JournalActa Neurologica Scandinavica
Volume66
Issue number3
StatePublished - 1982
Externally publishedYes

Fingerprint

Metrizamide
Blood-Brain Barrier
Glucose
Hexokinase
Vascular Endothelium
Deoxyglucose
Brain
Contrast Media
Phosphorylation
Cell Membrane
X-Rays

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

The blood-brain barrier is impermeable to metrizamide. / Gjedde, A.

In: Acta Neurologica Scandinavica, Vol. 66, No. 3, 1982, p. 392-395.

Research output: Contribution to journalArticle

Gjedde, A. / The blood-brain barrier is impermeable to metrizamide. In: Acta Neurologica Scandinavica. 1982 ; Vol. 66, No. 3. pp. 392-395.
@article{066b3c7a3eb242e99deb72ad03953d13,
title = "The blood-brain barrier is impermeable to metrizamide",
abstract = "The X-ray contrast material metrizamide is a glucose analog, related to 2-deoxy-D-glucose. The cerebral capillary endothelium, or blood-brain barrier, is completely impermeable to this compound. It is unlikely, therefore, that metrizamide passes any cell membranes. Since the affinity for rat brain hexokinase is three orders of magnitude below that of D-glucose, it is equally unlikely that metrizamide attains intracellular concentrations in brain sufficient to inhibit glucose phosphorylation.",
author = "A. Gjedde",
year = "1982",
language = "English (US)",
volume = "66",
pages = "392--395",
journal = "Acta Neurologica Scandinavica",
issn = "0001-6314",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - The blood-brain barrier is impermeable to metrizamide

AU - Gjedde, A.

PY - 1982

Y1 - 1982

N2 - The X-ray contrast material metrizamide is a glucose analog, related to 2-deoxy-D-glucose. The cerebral capillary endothelium, or blood-brain barrier, is completely impermeable to this compound. It is unlikely, therefore, that metrizamide passes any cell membranes. Since the affinity for rat brain hexokinase is three orders of magnitude below that of D-glucose, it is equally unlikely that metrizamide attains intracellular concentrations in brain sufficient to inhibit glucose phosphorylation.

AB - The X-ray contrast material metrizamide is a glucose analog, related to 2-deoxy-D-glucose. The cerebral capillary endothelium, or blood-brain barrier, is completely impermeable to this compound. It is unlikely, therefore, that metrizamide passes any cell membranes. Since the affinity for rat brain hexokinase is three orders of magnitude below that of D-glucose, it is equally unlikely that metrizamide attains intracellular concentrations in brain sufficient to inhibit glucose phosphorylation.

UR - http://www.scopus.com/inward/record.url?scp=0019961179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019961179&partnerID=8YFLogxK

M3 - Article

C2 - 6814161

AN - SCOPUS:0019961179

VL - 66

SP - 392

EP - 395

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 3

ER -