The biology of tobacco and nicotine: Bench to bedside

Phillip A. Dennis, Carter Van Waes, J. Silvio Gutkind, Kenneth J. Kellar, Charles Vinson, Alexey G. Mukhin, Margaret R. Spitz, Joan E. Bailey-Wilson, Grace Chao Yeh, Lucy M. Anderson, Jonathan S. Wiest

Research output: Contribution to journalArticle

Abstract

Strong epidemiologic evidence links smoking and cancer. An increased understanding of the molecular biology of tobacco-related cancers could advance progress toward improving smoking cessation and patient management. Knowledge gaps between tobacco addiction, tumorigenesis, and cancer brought an interdisciplinary group of investigators together to discuss "The Biology of Nicotine and Tobacco: Bench to Bedside." Presentations on the signaling pathways and pathogenesis in tobacco-related cancers, mouse models of addiction, imaging and regulation of nicotinic receptors, the genetic basis for tobacco carcinogenesis and development of lung cancer, and molecular mechanisms of carcinogenesis were heard. Importantly, new opportunities to use molecular biology to identify and abrogate tobacco-mediated carcinogenesis and to identify high-risk individuals were recognized.

Original languageEnglish (US)
Pages (from-to)764-767
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume14
Issue number4
DOIs
StatePublished - Apr 2005

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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