The biology of tobacco and nicotine: Bench to bedside

Phillip A. Dennis, Carter Van Waes, J. Silvio Gutkind, Kenneth J. Kellar, Charles Vinson, Alexey G. Mukhin, Margaret R. Spitz, Joan E. Bailey-Wilson, Grace Chao Yeh, Lucy M. Anderson, Jonathan S. Wiest

Research output: Contribution to journalArticle

Abstract

Strong epidemiologic evidence links smoking and cancer. An increased understanding of the molecular biology of tobacco-related cancers could advance progress toward improving smoking cessation and patient management. Knowledge gaps between tobacco addiction, tumorigenesis, and cancer brought an interdisciplinary group of investigators together to discuss "The Biology of Nicotine and Tobacco: Bench to Bedside." Presentations on the signaling pathways and pathogenesis in tobacco-related cancers, mouse models of addiction, imaging and regulation of nicotinic receptors, the genetic basis for tobacco carcinogenesis and development of lung cancer, and molecular mechanisms of carcinogenesis were heard. Importantly, new opportunities to use molecular biology to identify and abrogate tobacco-mediated carcinogenesis and to identify high-risk individuals were recognized.

Original languageEnglish (US)
Pages (from-to)764-767
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume14
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Nicotine
Tobacco
Carcinogenesis
Molecular Biology
Neoplasms
Nicotinic Receptors
Smoking Cessation
Lung Neoplasms
Smoking
Research Personnel

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Dennis, P. A., Van Waes, C., Gutkind, J. S., Kellar, K. J., Vinson, C., Mukhin, A. G., ... Wiest, J. S. (2005). The biology of tobacco and nicotine: Bench to bedside. Cancer Epidemiology Biomarkers and Prevention, 14(4), 764-767. https://doi.org/10.1158/1055-9965.EPI-04-0652

The biology of tobacco and nicotine : Bench to bedside. / Dennis, Phillip A.; Van Waes, Carter; Gutkind, J. Silvio; Kellar, Kenneth J.; Vinson, Charles; Mukhin, Alexey G.; Spitz, Margaret R.; Bailey-Wilson, Joan E.; Yeh, Grace Chao; Anderson, Lucy M.; Wiest, Jonathan S.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 14, No. 4, 04.2005, p. 764-767.

Research output: Contribution to journalArticle

Dennis, PA, Van Waes, C, Gutkind, JS, Kellar, KJ, Vinson, C, Mukhin, AG, Spitz, MR, Bailey-Wilson, JE, Yeh, GC, Anderson, LM & Wiest, JS 2005, 'The biology of tobacco and nicotine: Bench to bedside', Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 4, pp. 764-767. https://doi.org/10.1158/1055-9965.EPI-04-0652
Dennis PA, Van Waes C, Gutkind JS, Kellar KJ, Vinson C, Mukhin AG et al. The biology of tobacco and nicotine: Bench to bedside. Cancer Epidemiology Biomarkers and Prevention. 2005 Apr;14(4):764-767. https://doi.org/10.1158/1055-9965.EPI-04-0652
Dennis, Phillip A. ; Van Waes, Carter ; Gutkind, J. Silvio ; Kellar, Kenneth J. ; Vinson, Charles ; Mukhin, Alexey G. ; Spitz, Margaret R. ; Bailey-Wilson, Joan E. ; Yeh, Grace Chao ; Anderson, Lucy M. ; Wiest, Jonathan S. / The biology of tobacco and nicotine : Bench to bedside. In: Cancer Epidemiology Biomarkers and Prevention. 2005 ; Vol. 14, No. 4. pp. 764-767.
@article{4bb646a5afc245ca83ae4400d5983011,
title = "The biology of tobacco and nicotine: Bench to bedside",
abstract = "Strong epidemiologic evidence links smoking and cancer. An increased understanding of the molecular biology of tobacco-related cancers could advance progress toward improving smoking cessation and patient management. Knowledge gaps between tobacco addiction, tumorigenesis, and cancer brought an interdisciplinary group of investigators together to discuss {"}The Biology of Nicotine and Tobacco: Bench to Bedside.{"} Presentations on the signaling pathways and pathogenesis in tobacco-related cancers, mouse models of addiction, imaging and regulation of nicotinic receptors, the genetic basis for tobacco carcinogenesis and development of lung cancer, and molecular mechanisms of carcinogenesis were heard. Importantly, new opportunities to use molecular biology to identify and abrogate tobacco-mediated carcinogenesis and to identify high-risk individuals were recognized.",
author = "Dennis, {Phillip A.} and {Van Waes}, Carter and Gutkind, {J. Silvio} and Kellar, {Kenneth J.} and Charles Vinson and Mukhin, {Alexey G.} and Spitz, {Margaret R.} and Bailey-Wilson, {Joan E.} and Yeh, {Grace Chao} and Anderson, {Lucy M.} and Wiest, {Jonathan S.}",
year = "2005",
month = "4",
doi = "10.1158/1055-9965.EPI-04-0652",
language = "English (US)",
volume = "14",
pages = "764--767",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "4",

}

TY - JOUR

T1 - The biology of tobacco and nicotine

T2 - Bench to bedside

AU - Dennis, Phillip A.

AU - Van Waes, Carter

AU - Gutkind, J. Silvio

AU - Kellar, Kenneth J.

AU - Vinson, Charles

AU - Mukhin, Alexey G.

AU - Spitz, Margaret R.

AU - Bailey-Wilson, Joan E.

AU - Yeh, Grace Chao

AU - Anderson, Lucy M.

AU - Wiest, Jonathan S.

PY - 2005/4

Y1 - 2005/4

N2 - Strong epidemiologic evidence links smoking and cancer. An increased understanding of the molecular biology of tobacco-related cancers could advance progress toward improving smoking cessation and patient management. Knowledge gaps between tobacco addiction, tumorigenesis, and cancer brought an interdisciplinary group of investigators together to discuss "The Biology of Nicotine and Tobacco: Bench to Bedside." Presentations on the signaling pathways and pathogenesis in tobacco-related cancers, mouse models of addiction, imaging and regulation of nicotinic receptors, the genetic basis for tobacco carcinogenesis and development of lung cancer, and molecular mechanisms of carcinogenesis were heard. Importantly, new opportunities to use molecular biology to identify and abrogate tobacco-mediated carcinogenesis and to identify high-risk individuals were recognized.

AB - Strong epidemiologic evidence links smoking and cancer. An increased understanding of the molecular biology of tobacco-related cancers could advance progress toward improving smoking cessation and patient management. Knowledge gaps between tobacco addiction, tumorigenesis, and cancer brought an interdisciplinary group of investigators together to discuss "The Biology of Nicotine and Tobacco: Bench to Bedside." Presentations on the signaling pathways and pathogenesis in tobacco-related cancers, mouse models of addiction, imaging and regulation of nicotinic receptors, the genetic basis for tobacco carcinogenesis and development of lung cancer, and molecular mechanisms of carcinogenesis were heard. Importantly, new opportunities to use molecular biology to identify and abrogate tobacco-mediated carcinogenesis and to identify high-risk individuals were recognized.

UR - http://www.scopus.com/inward/record.url?scp=20144388820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20144388820&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-04-0652

DO - 10.1158/1055-9965.EPI-04-0652

M3 - Article

C2 - 15824140

AN - SCOPUS:20144388820

VL - 14

SP - 764

EP - 767

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 4

ER -