The biology of breast carcinoma

Judith Clancy Keen, Nancy E. Davidson

Research output: Contribution to journalArticlepeer-review

Abstract

The biology of breast carcinoma is complex, with multiple factors contributing to its development and progression. The current review focuses on the role of several critical genes including estrogen receptor, progesterone receptor, retinoic acid receptor-β, epidermal growth factor receptor family members, p53, BRCA1, and BRCA2 as risk factors for the development of disease, predictors of prognosis and response to therapy, and as therapeutic targets. Studies of the biology of these and other genes that contribute to the development and progression of breast carcinoma have had and will continue to have great impact on all aspects of disease management.

Original languageEnglish (US)
Pages (from-to)825-833
Number of pages9
JournalCancer
Volume97
Issue number3 SUPPL.
DOIs
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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