The biology and clinical utility of EBV monitoring in blood

Jennifer Kanakry, Richard F Ambinder

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epstein-Barr virus (EBV) DNA in blood can be quantified in peripheral blood mononuclear cells, in circulating cell-free (CCF) DNA specimens, or in whole blood. CCF viral DNA may be actively released or extruded from viable cells, packaged in virions or passively shed from cells during apoptosis or necrosis. In infectious mononucleosis, viral DNA is detected in each of these kinds of specimens, although it is only transiently detected in CCF specimens. In nasopharyngeal carcinoma, CCF EBV DNA is an established tumor marker. In EBV-associated Hodgkin lymphoma and in EBV-associated extranodal NK-/T-cell lymphoma, there is growing evidence for the utility of CCF DNA as a tumor marker.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Microbiology and Immunology
PublisherSpringer Verlag
Pages475-499
Number of pages25
Volume391
DOIs
StatePublished - Oct 1 2015

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume391
ISSN (Print)0070217X
ISSN (Electronic)21969965

Fingerprint

Human Herpesvirus 4
DNA
Viral DNA
Tumor Biomarkers
Extranodal NK-T-Cell Lymphoma
Infectious Mononucleosis
Hodgkin Disease
Virion
Blood Cells
Necrosis
Apoptosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology
  • Medicine(all)

Cite this

Kanakry, J., & Ambinder, R. F. (2015). The biology and clinical utility of EBV monitoring in blood. In Current Topics in Microbiology and Immunology (Vol. 391, pp. 475-499). (Current Topics in Microbiology and Immunology; Vol. 391). Springer Verlag. https://doi.org/10.1007/978-3-319-22834-1_17

The biology and clinical utility of EBV monitoring in blood. / Kanakry, Jennifer; Ambinder, Richard F.

Current Topics in Microbiology and Immunology. Vol. 391 Springer Verlag, 2015. p. 475-499 (Current Topics in Microbiology and Immunology; Vol. 391).

Research output: Chapter in Book/Report/Conference proceedingChapter

Kanakry, J & Ambinder, RF 2015, The biology and clinical utility of EBV monitoring in blood. in Current Topics in Microbiology and Immunology. vol. 391, Current Topics in Microbiology and Immunology, vol. 391, Springer Verlag, pp. 475-499. https://doi.org/10.1007/978-3-319-22834-1_17
Kanakry J, Ambinder RF. The biology and clinical utility of EBV monitoring in blood. In Current Topics in Microbiology and Immunology. Vol. 391. Springer Verlag. 2015. p. 475-499. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/978-3-319-22834-1_17
Kanakry, Jennifer ; Ambinder, Richard F. / The biology and clinical utility of EBV monitoring in blood. Current Topics in Microbiology and Immunology. Vol. 391 Springer Verlag, 2015. pp. 475-499 (Current Topics in Microbiology and Immunology).
@inbook{0d1bb249c8e14031aeb19bc41af82399,
title = "The biology and clinical utility of EBV monitoring in blood",
abstract = "Epstein-Barr virus (EBV) DNA in blood can be quantified in peripheral blood mononuclear cells, in circulating cell-free (CCF) DNA specimens, or in whole blood. CCF viral DNA may be actively released or extruded from viable cells, packaged in virions or passively shed from cells during apoptosis or necrosis. In infectious mononucleosis, viral DNA is detected in each of these kinds of specimens, although it is only transiently detected in CCF specimens. In nasopharyngeal carcinoma, CCF EBV DNA is an established tumor marker. In EBV-associated Hodgkin lymphoma and in EBV-associated extranodal NK-/T-cell lymphoma, there is growing evidence for the utility of CCF DNA as a tumor marker.",
author = "Jennifer Kanakry and Ambinder, {Richard F}",
year = "2015",
month = "10",
day = "1",
doi = "10.1007/978-3-319-22834-1_17",
language = "English (US)",
volume = "391",
series = "Current Topics in Microbiology and Immunology",
publisher = "Springer Verlag",
pages = "475--499",
booktitle = "Current Topics in Microbiology and Immunology",

}

TY - CHAP

T1 - The biology and clinical utility of EBV monitoring in blood

AU - Kanakry, Jennifer

AU - Ambinder, Richard F

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Epstein-Barr virus (EBV) DNA in blood can be quantified in peripheral blood mononuclear cells, in circulating cell-free (CCF) DNA specimens, or in whole blood. CCF viral DNA may be actively released or extruded from viable cells, packaged in virions or passively shed from cells during apoptosis or necrosis. In infectious mononucleosis, viral DNA is detected in each of these kinds of specimens, although it is only transiently detected in CCF specimens. In nasopharyngeal carcinoma, CCF EBV DNA is an established tumor marker. In EBV-associated Hodgkin lymphoma and in EBV-associated extranodal NK-/T-cell lymphoma, there is growing evidence for the utility of CCF DNA as a tumor marker.

AB - Epstein-Barr virus (EBV) DNA in blood can be quantified in peripheral blood mononuclear cells, in circulating cell-free (CCF) DNA specimens, or in whole blood. CCF viral DNA may be actively released or extruded from viable cells, packaged in virions or passively shed from cells during apoptosis or necrosis. In infectious mononucleosis, viral DNA is detected in each of these kinds of specimens, although it is only transiently detected in CCF specimens. In nasopharyngeal carcinoma, CCF EBV DNA is an established tumor marker. In EBV-associated Hodgkin lymphoma and in EBV-associated extranodal NK-/T-cell lymphoma, there is growing evidence for the utility of CCF DNA as a tumor marker.

UR - http://www.scopus.com/inward/record.url?scp=84943338912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943338912&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-22834-1_17

DO - 10.1007/978-3-319-22834-1_17

M3 - Chapter

C2 - 26428386

AN - SCOPUS:84943338912

VL - 391

T3 - Current Topics in Microbiology and Immunology

SP - 475

EP - 499

BT - Current Topics in Microbiology and Immunology

PB - Springer Verlag

ER -