TY - JOUR
T1 - The biological activity of soluble antigen-antibody complexes. II. Physical properties of soluble complexes having skin-irritating activity
AU - ISHIZAKA, K.
AU - ISHIZAKA, T.
AU - CAMPBELL, D. H.
PY - 1959/2/1
Y1 - 1959/2/1
N2 - Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. The mechanism of the reaction is not that of passive or reversed passive anaphylaxis. The complex itself is toxic. Skin activity of the complex depends on its composition. It has become obvious that the complex composed of two antigen molecules and one antibody molecule, (Ag(2)Ab), does not have the activity, whereas, Ag(3)Ab(2) and more complicated complexes do. The role of complement as well as speculation on the structural changes of antibody-antigen complexes is presented.
AB - Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. The mechanism of the reaction is not that of passive or reversed passive anaphylaxis. The complex itself is toxic. Skin activity of the complex depends on its composition. It has become obvious that the complex composed of two antigen molecules and one antibody molecule, (Ag(2)Ab), does not have the activity, whereas, Ag(3)Ab(2) and more complicated complexes do. The role of complement as well as speculation on the structural changes of antibody-antigen complexes is presented.
KW - ALLERGY/experimental
KW - ANTIGEN-ANTIBODY REACTIONS
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U2 - 10.1084/jem.109.2.127
DO - 10.1084/jem.109.2.127
M3 - Article
C2 - 13620844
AN - SCOPUS:84882387997
SN - 0022-1007
VL - 109
SP - 127
EP - 143
JO - The Journal of experimental medicine
JF - The Journal of experimental medicine
IS - 2
ER -