The biological activity of soluble antigen-antibody complexes. II. Physical properties of soluble complexes having skin-irritating activity

K. ISHIZAKA, T. ISHIZAKA, D. H. CAMPBELL

Research output: Contribution to journalArticle

Abstract

Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. The mechanism of the reaction is not that of passive or reversed passive anaphylaxis. The complex itself is toxic. Skin activity of the complex depends on its composition. It has become obvious that the complex composed of two antigen molecules and one antibody molecule, (Ag(2)Ab), does not have the activity, whereas, Ag(3)Ab(2) and more complicated complexes do. The role of complement as well as speculation on the structural changes of antibody-antigen complexes is presented.

Original languageEnglish (US)
Pages (from-to)127-143
Number of pages17
JournalThe Journal of experimental medicine
Volume109
Issue number2
DOIs
StatePublished - Feb 1 1959

Keywords

  • ALLERGY/experimental
  • ANTIGEN-ANTIBODY REACTIONS

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'The biological activity of soluble antigen-antibody complexes. II. Physical properties of soluble complexes having skin-irritating activity'. Together they form a unique fingerprint.

  • Cite this