The biologic scaffold immune microenvironment inhibits tumor formation and synergizes with immunotherapy

Matthew T. Wolf, Sudipto Ganguly, Radhika Narain, Kaitlyn Sadtler, Drew M. Pardoll, Jennifer H. Elisseeff

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Tissue engineering scaffolds are designed to create an environment that encourages tissue growth. However, many of the same processes and cells involved in tissue healing are associated with tumor progression, including immune cells. Cancer immunotherapy attempts to reverse tumor escape from immune clearance, but requires a responsive tumor microenvironment. It is currently unknown whether a pro-regenerative scaffold immune environment influences cancer progression or cancer immunotherapy. Biologic scaffolds prepared from decellularized tissues are at the crossroads of tissue engineering and surgical oncology as they aid in surgical reconstruction after tumor resection. We sought to determine the elements of a biologic scaffold immune microenvironment that affect tumor formation and cancer immunotherapy responses.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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