The binding of a synthetic progestin, r5020, to transcortin and serum albumin

Daniel W. Chan, W. R. Slaunwhite

Research output: Contribution to journalArticle

Abstract

R5020 (17,21 -dimethyl -19 -nor -4,9 -pregnadiene-3,20-dione), a synthetic progestin, was tested for its binding to purified human transcortin, albumin and human serum. Scatchard analysis showed that R5020 bound relatively weakly to transcortin (Kass = 8 × 106M–1); in 20% human serum or albumin greater than 90% was bound with low Kass and an indeterminate number of binding sites.

Original languageEnglish (US)
Pages (from-to)983-985
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume44
Issue number5
DOIs
StatePublished - May 1977
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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