The binding of a synthetic progestin, r5020, to transcortin and serum albumin

Daniel W. Chan; W. R. Slaunwhite

doi:10.1210/jcem-44-5-983

The binding of a synthetic progestin, r5020, to transcortin and serum albumin

Daniel W. Chan, W. R. Slaunwhite

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

R5020 (17,21 -dimethyl -19 -nor -4,9 -pregnadiene-3,20-dione), a synthetic progestin, was tested for its binding to purified human transcortin, albumin and human serum. Scatchard analysis showed that R5020 bound relatively weakly to transcortin (Kass = 8 × 10⁶M^–1); in 20% human serum or albumin greater than 90% was bound with low Kass and an indeterminate number of binding sites.

Original language	English (US)
Pages (from-to)	983-985
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	44
Issue number	5
DOIs	https://doi.org/10.1210/jcem-44-5-983
State	Published - May 1977
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

Access to Document

10.1210/jcem-44-5-983

Cite this

@article{ceca9745d5284327924c42cfc69b545a,

title = "The binding of a synthetic progestin, r5020, to transcortin and serum albumin",

abstract = "R5020 (17,21 -dimethyl -19 -nor -4,9 -pregnadiene-3,20-dione), a synthetic progestin, was tested for its binding to purified human transcortin, albumin and human serum. Scatchard analysis showed that R5020 bound relatively weakly to transcortin (Kass = 8 × 106M–1); in 20% human serum or albumin greater than 90% was bound with low Kass and an indeterminate number of binding sites.",

author = "Chan, {Daniel W.} and Slaunwhite, {W. R.}",

year = "1977",

month = may,

doi = "10.1210/jcem-44-5-983",

language = "English (US)",

volume = "44",

pages = "983--985",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "The Endocrine Society",

number = "5",

}

TY - JOUR

T1 - The binding of a synthetic progestin, r5020, to transcortin and serum albumin

AU - Chan, Daniel W.

AU - Slaunwhite, W. R.

PY - 1977/5

Y1 - 1977/5

N2 - R5020 (17,21 -dimethyl -19 -nor -4,9 -pregnadiene-3,20-dione), a synthetic progestin, was tested for its binding to purified human transcortin, albumin and human serum. Scatchard analysis showed that R5020 bound relatively weakly to transcortin (Kass = 8 × 106M–1); in 20% human serum or albumin greater than 90% was bound with low Kass and an indeterminate number of binding sites.

AB - R5020 (17,21 -dimethyl -19 -nor -4,9 -pregnadiene-3,20-dione), a synthetic progestin, was tested for its binding to purified human transcortin, albumin and human serum. Scatchard analysis showed that R5020 bound relatively weakly to transcortin (Kass = 8 × 106M–1); in 20% human serum or albumin greater than 90% was bound with low Kass and an indeterminate number of binding sites.

UR - http://www.scopus.com/inward/record.url?scp=0017683078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017683078&partnerID=8YFLogxK

U2 - 10.1210/jcem-44-5-983

DO - 10.1210/jcem-44-5-983

M3 - Article

C2 - 858781

AN - SCOPUS:0017683078

SN - 0021-972X

VL - 44

SP - 983

EP - 985

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 5

ER -

The binding of a synthetic progestin, r5020, to transcortin and serum albumin

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this