The binding of a synthetic progestin, R5020, to transcortin and serum albumin

Daniel Wan-Yui Chan, W. R. Slaunwhite

Research output: Contribution to journalArticle

Abstract

R5020 (17,21 - dimethyl - 19 - nor - 4,9 - pregnadiene - 3,20-dione), a synthetic progestin, was tested for its binding to purified human transcortin, albumin and human serum. Scatchard analysis showed that R5020 bound relatively weakly to transcortin (Kass = 8 x 106M-1); in 20% human serum or albumin greater than 90% was bound with low Kass and an indeterminate number of binding sites.

Original languageEnglish (US)
Pages (from-to)983-985
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume44
Issue number5
StatePublished - 1977
Externally publishedYes

Fingerprint

Promegestone
Progesterone Congeners
Transcortin
Serum Albumin
Albumins
Binding Sites

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

The binding of a synthetic progestin, R5020, to transcortin and serum albumin. / Chan, Daniel Wan-Yui; Slaunwhite, W. R.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 44, No. 5, 1977, p. 983-985.

Research output: Contribution to journalArticle

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