TY - JOUR
T1 - The benefits and risks of ECT for patients with primary dementia who also suffer from depression
AU - Rao, Vani
AU - Lyketsos, Constantine G.
PY - 2000
Y1 - 2000
N2 - Background. Major depression afflicts 20-25% of patients with dementia. Of these, about a third do not improve with antidepressant therapy and may be suitable candidates for electroconvulsive treatment (ECT). However, the use of ECT in dementia patients is concerning due to possibble adverse effects on memory and cognition. Outcome studies of ECT in patients with primary dementia and depression are very rare. Objective. To determine the effectiveness and complications of ECT treatment for depression in dementia. Method. A chart review was conducted of all 31 patients with a discharge diagnosis of 'Dementia with depression' treated with ECT at the Johns Hopkins Hospital, over a five-year period. Admission and discharge ratings were made on the Mini-Mental State Examination (MMSE) and the Montgomery-Asberg Depression Rating Scale (MADRS) as part of the clinical routine. Results. All patients suffered from dementia: 55% had vascular dementia, 13% Alzheimer's disease, and 32% degenerative dementia of uncertain etiology. The admission MADRS mean score was 27.5 (SD 8.1) and the MMSE mean score was 18.8 (SD 5.5). The patients received between 1 and 23 ECT treatments (mean 9, SD 5.7). At discharge, there was a statistically significant mean decline on the MADRS of 12.28 points (p < 0.01). Forty percent had scores less than 10 (normal) on the MADRS. While 49% of patients developed delirium, by discharge there was also a significant mean increase (improvement) in MMSE of 1.62 points (p < 0.02). Conclusions. ECT is an effective treatment for depression in dementia, leading to improvements in both mood and cognition. Multiple ECT treatments may be necessary before a significant improvement in mood is achieved. Copyright (C) 2000 John Wiley and Sons, Ltd.
AB - Background. Major depression afflicts 20-25% of patients with dementia. Of these, about a third do not improve with antidepressant therapy and may be suitable candidates for electroconvulsive treatment (ECT). However, the use of ECT in dementia patients is concerning due to possibble adverse effects on memory and cognition. Outcome studies of ECT in patients with primary dementia and depression are very rare. Objective. To determine the effectiveness and complications of ECT treatment for depression in dementia. Method. A chart review was conducted of all 31 patients with a discharge diagnosis of 'Dementia with depression' treated with ECT at the Johns Hopkins Hospital, over a five-year period. Admission and discharge ratings were made on the Mini-Mental State Examination (MMSE) and the Montgomery-Asberg Depression Rating Scale (MADRS) as part of the clinical routine. Results. All patients suffered from dementia: 55% had vascular dementia, 13% Alzheimer's disease, and 32% degenerative dementia of uncertain etiology. The admission MADRS mean score was 27.5 (SD 8.1) and the MMSE mean score was 18.8 (SD 5.5). The patients received between 1 and 23 ECT treatments (mean 9, SD 5.7). At discharge, there was a statistically significant mean decline on the MADRS of 12.28 points (p < 0.01). Forty percent had scores less than 10 (normal) on the MADRS. While 49% of patients developed delirium, by discharge there was also a significant mean increase (improvement) in MMSE of 1.62 points (p < 0.02). Conclusions. ECT is an effective treatment for depression in dementia, leading to improvements in both mood and cognition. Multiple ECT treatments may be necessary before a significant improvement in mood is achieved. Copyright (C) 2000 John Wiley and Sons, Ltd.
KW - Dementia
KW - Depression
KW - ECT
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U2 - 10.1002/1099-1166(200008)15:8<729::AID-GPS193>3.0.CO;2-A
DO - 10.1002/1099-1166(200008)15:8<729::AID-GPS193>3.0.CO;2-A
M3 - Article
C2 - 10960885
AN - SCOPUS:0033831586
SN - 0885-6230
VL - 15
SP - 729
EP - 735
JO - International journal of geriatric psychiatry
JF - International journal of geriatric psychiatry
IS - 8
ER -