The beginning of the road for non-coding RNAs in normal hematopoiesis and hematologic malignancies

Elisabeth F. Heuston; Kenya T. Lemon; Robert J. Arceci

doi:10.3389/fgene.2011.00094

The beginning of the road for non-coding RNAs in normal hematopoiesis and hematologic malignancies

Elisabeth F. Heuston, Kenya T. Lemon, Robert J. Arceci

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

The field of non-coding RNAs (ncRNAs) encompasses a wide array of RNA classes that are indispensible for the regulation of cellular activities. However, de-regulation of these ncRNAs can also play key roles in malignant transformation and cancer cell behavior. In this article we survey a select group of microRNAs and long ncRNAs that appear to contribute in keys ways to the development of acute and chronic leukemias, as well as contribute to their diagnosis, prognosis, and potentially, their treatment.

Original language	English (US)
Article number	Article 94
Journal	Frontiers in Genetics
Volume	2
Issue number	DEC
DOIs	https://doi.org/10.3389/fgene.2011.00094
State	Published - 2011
Externally published	Yes

Keywords

ALL
AML
CLL
CML
Non-coding RNA

ASJC Scopus subject areas

Molecular Medicine
Genetics
Genetics(clinical)

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10.3389/fgene.2011.00094

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AB - The field of non-coding RNAs (ncRNAs) encompasses a wide array of RNA classes that are indispensible for the regulation of cellular activities. However, de-regulation of these ncRNAs can also play key roles in malignant transformation and cancer cell behavior. In this article we survey a select group of microRNAs and long ncRNAs that appear to contribute in keys ways to the development of acute and chronic leukemias, as well as contribute to their diagnosis, prognosis, and potentially, their treatment.

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KW - AML

KW - CLL

KW - CML

KW - Non-coding RNA

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The beginning of the road for non-coding RNAs in normal hematopoiesis and hematologic malignancies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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