The bed nucleus-amygdala continuum in human and monkey

L. J. Martin, Lee J Martin, T. L. Dellovade, D. L. Price

Research output: Contribution to journalArticle

Abstract

The cytoarchitecture and distributions of seven neuropeptides were examined in the bed nucleus of the stria terminalis (BST), substantia innominata (SI), and central and medial nuclei of the amygdala of human and monkey to determine whether neurons of these regions form an anatomical continuum in primate brain. The BST and centromedial amygdala have common cyto- and chemo-architectonic characteristics, and these regions are components of a distinct neuronal complex. This neuronal continuum extends dorsally, with the stria terminalis, from the BST and merges with the amygdala; it extends ventrally from the BST through the SI to the centromedial amygdala. The cytoarchitectonics of the BST-amygdala complex are heterogeneous and compartmental. The BST is parcellated broadly into anterior, lateral, medial, ventral, supracapsular, and sublenticular divisions. The central and medial nuclei of the amygdala are also parcellated into several subdivisions. Neurons of central and medial nuclei of the amygdala are similar to neurons in the lateral and medial divisions of the BST, respectively. Neurons in the SI form cellular bridges between the BST and amygdala. The BST, SI, and amygdala share several neuropeptide transmitters, and patterns of peptide immunoreactivity parallel cytological findings. Specific chemoarchitectonic zones were delineated by perikaryal, peridendritic/perisomatic, axonal, and terminal immunoreactivities. The results of this investigation demonstrate that there is a neuronal continuity between the BST and amygdala and that the BST-amygdala complex is prominent and discretely compartmental in forebrains of human and monkey.

Original languageEnglish (US)
Pages (from-to)445-485
Number of pages41
JournalJournal of Comparative Neurology
Volume309
Issue number4
StatePublished - 1991

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Septal Nuclei
Amygdala
Haplorhini
Substantia Innominata
Intralaminar Thalamic Nuclei
Neurons
Neuropeptides
Prosencephalon
Primates

Keywords

  • basal forebrain
  • enkephalin
  • neurotensin
  • somatostatin
  • substantia innominata

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Martin, L. J., Martin, L. J., Dellovade, T. L., & Price, D. L. (1991). The bed nucleus-amygdala continuum in human and monkey. Journal of Comparative Neurology, 309(4), 445-485.

The bed nucleus-amygdala continuum in human and monkey. / Martin, L. J.; Martin, Lee J; Dellovade, T. L.; Price, D. L.

In: Journal of Comparative Neurology, Vol. 309, No. 4, 1991, p. 445-485.

Research output: Contribution to journalArticle

Martin, LJ, Martin, LJ, Dellovade, TL & Price, DL 1991, 'The bed nucleus-amygdala continuum in human and monkey', Journal of Comparative Neurology, vol. 309, no. 4, pp. 445-485.
Martin, L. J. ; Martin, Lee J ; Dellovade, T. L. ; Price, D. L. / The bed nucleus-amygdala continuum in human and monkey. In: Journal of Comparative Neurology. 1991 ; Vol. 309, No. 4. pp. 445-485.
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