The basis of molecular strategies for treating coronary restenosis after angioplasty

Stephen E. Epstein, Edith Speir, Ellis F. Unger, Raul J. Guzman, Toren Finkel

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


Excessive smooth muscle cell proliferation significantly contributes to restenosis, which occurs in 25% to 50% of patients within 6 months of coronary angioplasty. Because successful treatment will probably depend on our acquiring a comprehensive knowledge of the molecular and cellular mechanisms involved, this report reviews 1) information relevant to the molecular and cellular mechanisms responsible for the smooth muscle cell(s) response to vascular injury, and 2) several molecular-based therapeutic strategies currently being explored as possible approaches to the control of restenosis, including recombinant DNA technology to target delivery of cytotoxic molecules to proliferating smooth muscle cell(s), antisense strategies to inhibit expression of gene products necessary for cell proliferation and gene therapy.

Original languageEnglish (US)
Pages (from-to)1278-1288
Number of pages11
JournalJournal of the American College of Cardiology
Issue number6
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Nursing(all)


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