The balance of the evidence on acid-base homeostasis and progression of chronic kidney disease

Julia J. Scialla

Research output: Contribution to journalComment/debate

Abstract

Normalization of acid-base homeostasis in chronic kidney disease (CKD) holds promise for mitigating disease progression, but whether efforts should focus on patients with low serum bicarbonate or high dietary acid load is unknown. Vallet et al. report that low urinary ammonia excretion independently associates with increased progression in moderate CKD. Whether this finding implicates differences in endogenous acid production or the ability to excrete an acid load in the pathogenesis of progression requires further study.

Original languageEnglish (US)
Pages (from-to)9-11
Number of pages3
JournalKidney international
Volume88
Issue number1
DOIs
StatePublished - Jul 2 2015

ASJC Scopus subject areas

  • Nephrology

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