The Balance Between Excitation And Inhibition And Functional Sensory Processing In The Somatosensory Cortex

Zhi Zhang, Qian Quan Sun

Research output: Contribution to journalArticle

Abstract

The balance between excitation and inhibition (E/I balance) is tightly regulated in adult cortices to maintain proper nervous system function. Disturbed E/I balance is associated with numerous neuropsychological disorders, such as autism, epilepsy and schizophrenia. The present review will discuss aspects of Hebbian and homeostatic mechanisms regulating excitatory and inhibitory balance related to sensory processing in somatosensory cortex of rodents. Additionally, changes in the E/I balance during sensory manipulation will be discussed.

Original languageEnglish (US)
Pages (from-to)305-332
Number of pages28
JournalInternational Review of Neurobiology
Volume97
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Somatosensory Cortex
Autistic Disorder
Nervous System
Rodentia
Epilepsy
Schizophrenia
Inhibition (Psychology)

Keywords

  • Critical period
  • E/I balance
  • GABAergic interneuron
  • Neocortex
  • NMDA receptors
  • Postnatal development

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

The Balance Between Excitation And Inhibition And Functional Sensory Processing In The Somatosensory Cortex. / Zhang, Zhi; Sun, Qian Quan.

In: International Review of Neurobiology, Vol. 97, 2011, p. 305-332.

Research output: Contribution to journalArticle

@article{c2ce0e625b56420f9e778fe7bc91db20,
title = "The Balance Between Excitation And Inhibition And Functional Sensory Processing In The Somatosensory Cortex",
abstract = "The balance between excitation and inhibition (E/I balance) is tightly regulated in adult cortices to maintain proper nervous system function. Disturbed E/I balance is associated with numerous neuropsychological disorders, such as autism, epilepsy and schizophrenia. The present review will discuss aspects of Hebbian and homeostatic mechanisms regulating excitatory and inhibitory balance related to sensory processing in somatosensory cortex of rodents. Additionally, changes in the E/I balance during sensory manipulation will be discussed.",
keywords = "Critical period, E/I balance, GABAergic interneuron, Neocortex, NMDA receptors, Postnatal development",
author = "Zhi Zhang and Sun, {Qian Quan}",
year = "2011",
doi = "10.1016/B978-0-12-385198-7.00012-6",
language = "English (US)",
volume = "97",
pages = "305--332",
journal = "International Review of Neurobiology",
issn = "0074-7742",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - The Balance Between Excitation And Inhibition And Functional Sensory Processing In The Somatosensory Cortex

AU - Zhang, Zhi

AU - Sun, Qian Quan

PY - 2011

Y1 - 2011

N2 - The balance between excitation and inhibition (E/I balance) is tightly regulated in adult cortices to maintain proper nervous system function. Disturbed E/I balance is associated with numerous neuropsychological disorders, such as autism, epilepsy and schizophrenia. The present review will discuss aspects of Hebbian and homeostatic mechanisms regulating excitatory and inhibitory balance related to sensory processing in somatosensory cortex of rodents. Additionally, changes in the E/I balance during sensory manipulation will be discussed.

AB - The balance between excitation and inhibition (E/I balance) is tightly regulated in adult cortices to maintain proper nervous system function. Disturbed E/I balance is associated with numerous neuropsychological disorders, such as autism, epilepsy and schizophrenia. The present review will discuss aspects of Hebbian and homeostatic mechanisms regulating excitatory and inhibitory balance related to sensory processing in somatosensory cortex of rodents. Additionally, changes in the E/I balance during sensory manipulation will be discussed.

KW - Critical period

KW - E/I balance

KW - GABAergic interneuron

KW - Neocortex

KW - NMDA receptors

KW - Postnatal development

UR - http://www.scopus.com/inward/record.url?scp=79959620975&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959620975&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-385198-7.00012-6

DO - 10.1016/B978-0-12-385198-7.00012-6

M3 - Article

VL - 97

SP - 305

EP - 332

JO - International Review of Neurobiology

JF - International Review of Neurobiology

SN - 0074-7742

ER -