The B-cell-specific src-family kinase Blk is dispensable for B-cell development and activation

Gemma Texido, I. Hsin Su, Ingrid Mecklenbräuker, Kaoru Saijo, Sami N. Malek, Stephen Desiderio, Klaus Rajewsky, Alexander Tarakhovsky

Research output: Contribution to journalArticle

Abstract

The B-cell lymphocyte kinase (Blk) is a src-family protein tyrosine kinase specifically expressed in B-lineage cells of mice. The early onset of Blk expression during B-cell development in the bone marrow and the high expression levels of Blk in mature B cells suggest a possible important role of Blk in B-cell physiology. To study the in vivo function of Blk, mice homozygous for the targeted disruption of the blk gene were generated. In homozygous mutant mice, neither blk mRNA nor Blk protein is expressed. Despite the absence of Blk, the development, in vitro activation, and humoral immune responses of B cells to T-cell-dependent and -independent antigens are unaltered. These data are consistent with functional redundancy of Blk in B- cell development and immune responses.

Original languageEnglish (US)
Pages (from-to)1227-1233
Number of pages7
JournalMolecular and cellular biology
Volume20
Issue number4
DOIs
StatePublished - Feb 1 2000

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Texido, G., Su, I. H., Mecklenbräuker, I., Saijo, K., Malek, S. N., Desiderio, S., Rajewsky, K., & Tarakhovsky, A. (2000). The B-cell-specific src-family kinase Blk is dispensable for B-cell development and activation. Molecular and cellular biology, 20(4), 1227-1233. https://doi.org/10.1128/MCB.20.4.1227-1233.2000