TY - JOUR
T1 - The B-cell-specific src-family kinase Blk is dispensable for B-cell development and activation
AU - Texido, Gemma
AU - Su, I. Hsin
AU - Mecklenbräuker, Ingrid
AU - Saijo, Kaoru
AU - Malek, Sami N.
AU - Desiderio, Stephen
AU - Rajewsky, Klaus
AU - Tarakhovsky, Alexander
PY - 2000/2
Y1 - 2000/2
N2 - The B-cell lymphocyte kinase (Blk) is a src-family protein tyrosine kinase specifically expressed in B-lineage cells of mice. The early onset of Blk expression during B-cell development in the bone marrow and the high expression levels of Blk in mature B cells suggest a possible important role of Blk in B-cell physiology. To study the in vivo function of Blk, mice homozygous for the targeted disruption of the blk gene were generated. In homozygous mutant mice, neither blk mRNA nor Blk protein is expressed. Despite the absence of Blk, the development, in vitro activation, and humoral immune responses of B cells to T-cell-dependent and -independent antigens are unaltered. These data are consistent with functional redundancy of Blk in B- cell development and immune responses.
AB - The B-cell lymphocyte kinase (Blk) is a src-family protein tyrosine kinase specifically expressed in B-lineage cells of mice. The early onset of Blk expression during B-cell development in the bone marrow and the high expression levels of Blk in mature B cells suggest a possible important role of Blk in B-cell physiology. To study the in vivo function of Blk, mice homozygous for the targeted disruption of the blk gene were generated. In homozygous mutant mice, neither blk mRNA nor Blk protein is expressed. Despite the absence of Blk, the development, in vitro activation, and humoral immune responses of B cells to T-cell-dependent and -independent antigens are unaltered. These data are consistent with functional redundancy of Blk in B- cell development and immune responses.
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U2 - 10.1128/MCB.20.4.1227-1233.2000
DO - 10.1128/MCB.20.4.1227-1233.2000
M3 - Article
C2 - 10648608
AN - SCOPUS:0033969955
SN - 0270-7306
VL - 20
SP - 1227
EP - 1233
JO - Molecular and cellular biology
JF - Molecular and cellular biology
IS - 4
ER -