The B cell antigen receptor in B-cell development

Research output: Contribution to journalArticlepeer-review


During B-cell development, immature and mature forms of the B cell antigen receptor complex are deployed in a regulated fashion; thus, B cell antigen receptor complexes play essential roles in the transit of cells through ontogeny. The past year has seen progress in our understanding of how antigen receptor gene assembly is controlled and in defining the requirements for antigen receptor mediated signaling at specific developmental stages. The discovery that a defective protein tyrosine kinase is responsible for X-linked agammaglobulinemia in man and X-linked immunodeficiency in the mouse is particularly interesting, as it may provide the means to link a specific intracellular signaling pathway with a particular step in B-cell development.

Original languageEnglish (US)
Pages (from-to)248-256
Number of pages9
JournalCurrent Opinion in Immunology
Issue number2
StatePublished - Apr 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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